Mateti Uday Venkat, Lalwani Tarachand, Nagappa Anantha Naik, Bhandary P V, Verupaksha D, Balkrishnan Rajesh
Department of Pharmacy Management, Manipal College of Pharmaceutical Sciences. Manipal University, Manipal, Karnataka, India.
Department of Clinical Pharmacy, Kalupur Bank Institute of Pharmaceutical Education and Research, Gandhinagar, Gujarat, India.
Perspect Clin Res. 2015 Jan-Mar;6(1):58-61. doi: 10.4103/2229-3485.148820.
Drug-related problems (DRPs) frequently occur in modern medical practice, increasing the morbidity and mortality as well as increasing cost of care.
The study is to evaluate the incidence of DRPs in patients admitted to a psychiatric department.
A prospective observational study was conducted for a period of 4 months at Baliga psychiatric hospital. All prescriptions of the study population were screened for DRPs such as adverse drug reactions (ADRs) and potential drug-drug interactions (pDDIs) by using computerized database system.
Out of 120 patients, 19 patients had observed 26 DRPs. Out of 33 patients, 19 patients had observed 26 ADRs and 14 patients had observed 24 pDDIs. The overall incidence of DRPs was 15.83%. Female patients outnumbered the male patients, in which 12 women constitute 10% followed by men 7 (5.83%). The common ADRs observed were hyponatremia and headache. Considering the outcomes, 20 (76.9%) cases recovered from ADRs and 20 (76.9%) of the ADRs were definitely preventable. Majority of ADRs were probable and were found to be mild to moderately severe.
Age, female gender and polypharmacy were the risk factors for the developing DRPs.
药物相关问题（DRPs）在现代医疗实践中频繁出现，增加了发病率和死亡率，同时也增加了护理成本。
本研究旨在评估精神科住院患者中DRPs的发生率。
在巴利加精神病医院进行了为期4个月的前瞻性观察研究。使用计算机数据库系统对研究人群的所有处方进行DRPs筛查，如药物不良反应（ADRs）和潜在药物相互作用（pDDIs）。
120例患者中，19例患者出现了26例DRPs。33例患者中，19例患者出现了26例ADRs，14例患者出现了24例pDDIs。DRPs的总体发生率为15.83%。女性患者多于男性患者，其中12名女性占10%，其次是男性7名（5.83%）。观察到的常见ADRs为低钠血症和头痛。考虑到结果，20例（76.9%）ADR病例康复，20例（76.9%）ADRs肯定是可以预防的。大多数ADRs是可能的，且被发现为轻度至中度严重。
年龄、女性性别和联合用药是发生DRPs的危险因素。
