Dagnew Ephrem Mebratu, Ayalew Mohammed Biset, Alemnew Mekonnen Gizework, Geremew Alehegn Bishaw, Abdela Ousman Abubeker
Department of Pharmacy, College of Health Sciences, Debre Markos University, Debre Markos, Ethiopia.
Department of Clinical Pharmacy, School of Pharmacy, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
SAGE Open Med. 2022 Aug 22;10:20503121221112485. doi: 10.1177/20503121221112485. eCollection 2022.
To determine the prevalence of drug-related problems and the factors influencing them among adult psychiatric inpatients.
A multi-centre cross-sectional observational study was conducted from April to July 2021 at five randomly selected hospitals in Northwest Ethiopia. A total of 325 consecutively sampled patients participated in the study. Clinical pharmacists assessed the drug-related problems based on clinical judgement supported by updated evidence-based disease guidelines. We used the Medscape drug-interactions checker to check drug-to-drug interactions. The results were summarised using descriptive statistics, including frequency, mean, and standard deviation. For each variable, an odds ratio with a 95% confidence interval was calculated, as well as the related -value. The value of ⩽ 0.05 was considered statistically significant.
From the total number of 325 study participants, more than half of them (52.9%) were females, and the mean age ± (standard deviation) was 30.8 ± 11.3 years. At least one drug-related problem was recorded by 60.9% to 95% confidence interval (55.7-65.8) of study participants, with a mean of 0.6 ± 0.49 per patient. Additional drug therapy was the most common drug-related problem (22.8%) followed by non-adherence to medicine (20.6%) and adverse drug reactions (11%), respectively. Factors independent associated with drug-related problems were rural residence (adjusted odds ratio = 1.96, 95% confidence interval: 1.01-2.84, -value = 0.046), self-employed (adjusted odds ratio = 6.0, 95% confidence interval: 1.0-36.9, -value = 0.035) and alcohol drinkers (adjusted odds ratio = 6.40, 95% confidence interval: 1.12-37.5, -value = 0.034).
The prevalence of drug-related problems among adult psychiatric patients admitted to psychiatric wards was high. Healthcare providers give more attention to tackling these problems. Being a rural resident, self-employed, and alcohol drinkers were associated with drug-related problems.
确定成年精神科住院患者中药物相关问题的患病率及其影响因素。
2021年4月至7月，在埃塞俄比亚西北部随机选取的五家医院开展了一项多中心横断面观察性研究。共有325名连续抽样的患者参与了该研究。临床药师根据最新循证疾病指南支持的临床判断评估药物相关问题。我们使用Medscape药物相互作用检查器来检查药物间相互作用。结果采用描述性统计进行总结，包括频率、均值和标准差。对于每个变量，计算了比值比及其95%置信区间，以及相关的P值。P值≤0.05被认为具有统计学意义。
在325名研究参与者中，超过一半（52.9%）为女性，平均年龄±（标准差）为30.8±11.3岁。60.9%至95%置信区间（55.7 - 65.8）的研究参与者记录到至少一个药物相关问题，平均每位患者0.6±0.49个。额外药物治疗是最常见的药物相关问题（22.8%），其次分别是非依从性用药（20.6%）和药物不良反应（11%）。与药物相关问题独立相关的因素为农村居住（调整后比值比 = 1.96，95%置信区间：1.01 - 2.84，P值 = 0.046）、个体经营者（调整后比值比 = 6.0，95%置信区间：1.0 - 36.9，P值 = 0.035）和饮酒者（调整后比值比 = 6.40，95%置信区间：1.12 - 37.5，P值 = 0.034）。
入住精神科病房的成年精神科患者中药物相关问题的患病率较高。医疗服务提供者应更加关注解决这些问题。农村居民、个体经营者和饮酒者与药物相关问题有关。
