Faria Bruno M, Duman Fulya, Zheng Cindy X, Waisbourd Michael, Gupta Lalita, Ali Mohsin, Zangalli Camila, Lu Lan, Wizov Sheryl S, Spaeth Eric, Richman Jesse, Spaeth George L
Wills Eye Hospital Glaucoma Research Center, Philadelphia, Pennsylvania.
Retina. 2015 Jul;35(7):1465-73. doi: 10.1097/IAE.0000000000000474.
Contrast sensitivity (CS) is a valuable measure of visual function in patients with age-related macular degeneration (AMD). The authors aimed to compare a novel computer-based test (the Spaeth/Richman Contrast Sensitivity test) with Pelli-Robson test for evaluating CS in patients with AMD.
In this prospective cross-sectional study, CS was evaluated in patients with various stages of AMD and healthy controls using Spaeth/Richman Contrast Sensitivity test and Pelli-Robson test. Spaeth/Richman Contrast Sensitivity test determined CS scores for 5 areas of vision for each eye (central, superonasal, superotemporal, inferonasal, and inferotemporal) and the total score. Test scores between the two methods were compared using mixed-effects linear regression. Spearman's rank correlation coefficient was used to determine correlations. Test-retest reliability was determined using the intraclass correlation coefficient.
Of 35 participants with AMD (54 eyes) and 34 controls (66 eyes), 51% were female and 93% were of European descent. The mean Spaeth/Richman Contrast Sensitivity test score for the central area and each of the 4 peripheral quadrants was significantly lower for patients with AMD versus controls (P < 0.001 for all). The mean Pelli-Robson score was also significantly lower in patients with AMD versus controls (P < 0.001). The intraclass correlation coefficient for Spaeth/Richman Contrast Sensitivity test total score and Pelli-Robson score was 0.87 and 0.92, respectively.
Spaeth/Richman Contrast Sensitivity test, a novel Internet-based method of testing CS, had significantly lower scores for patients with AMD compared with controls for central and peripheral vision. This test is a valuable tool for assessing CS in AMD.
对比敏感度（CS）是评估年龄相关性黄斑变性（AMD）患者视觉功能的一项重要指标。作者旨在比较一种新型的基于计算机的测试（斯佩思/里奇曼对比敏感度测试）与佩利-罗布森测试在评估AMD患者CS方面的效果。
在这项前瞻性横断面研究中，使用斯佩思/里奇曼对比敏感度测试和佩利-罗布森测试对不同阶段的AMD患者和健康对照者的CS进行评估。斯佩思/里奇曼对比敏感度测试确定了每只眼睛5个视觉区域（中央、鼻上、颞上、鼻下和颞下）的CS分数以及总分。使用混合效应线性回归比较两种方法的测试分数。采用斯皮尔曼等级相关系数来确定相关性。使用组内相关系数确定重测信度。
35例AMD患者（共54只眼）和34例对照者（共66只眼）中，51%为女性，93%为欧洲血统。AMD患者中央区域以及4个周边象限的斯佩思/里奇曼对比敏感度测试平均分数均显著低于对照者（所有P值均<0.001）。AMD患者的佩利-罗布森平均分数也显著低于对照者（P<0.001）。斯佩思/里奇曼对比敏感度测试总分和佩利-罗布森分数的组内相关系数分别为0.87和0.92。
斯佩思/里奇曼对比敏感度测试是一种新型的基于互联网的CS测试方法，与对照者相比，AMD患者中央和周边视力的测试分数显著更低。该测试是评估AMD患者CS的一项重要工具。
