Ackerman David G, Feigenson Gerald W
Department of Molecular Biology and Genetics, Field of Biophysics, Cornell University, Ithaca, NY 14853, U.S.A.
Essays Biochem. 2015;57:33-42. doi: 10.1042/bse0570033.
In the present chapter we discuss the complex mixing behaviour of plasma membrane lipids. To do so, we first introduce the plasma membrane and membrane mixtures often used to model its complexity. We then discuss the nature of lipid phase behaviour in bilayers and the distinction between these phases and other manifestations of non-random mixing found in one-phase mixtures, such as clusters, micelles and microemulsions. Finally, we demonstrate the applicability of Gibbs phase diagrams to the study of increasingly complex model membrane systems, with a focus on phase coexistence, morphology and their implications for the cell plasma membrane.
在本章中，我们将讨论质膜脂质的复杂混合行为。为此，我们首先介绍质膜以及常用于模拟其复杂性的膜混合物。然后，我们将讨论双层脂质相行为的本质，以及这些相与单相混合物中发现的非随机混合的其他表现形式（如聚集体、胶束和微乳液）之间的区别。最后，我们将展示吉布斯相图在研究日益复杂的模型膜系统中的适用性，重点关注相共存、形态及其对细胞质膜的影响。
