MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK.
MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK.
Cell Stem Cell. 2015 Feb 5;16(2):111-2. doi: 10.1016/j.stem.2015.01.009.
For more than 60 years, we have known that the incidence of certain common human cancers increases with age. Recently in Science, Tomasetti and Vogelstein (2015) refined this model by providing a potential explanation, arguing that early random mutational events within individual stem cells of regenerating organs may underlie this correlation.
六十多年来，我们已经知道某些常见人类癌症的发病率会随着年龄的增长而增加。最近，在《科学》杂志上，Tomasetti 和 Vogelstein（2015）通过提供一个潜在的解释来完善这个模型，他们认为再生器官中个体干细胞内的早期随机突变事件可能是这种相关性的基础。
