Laurin J, Pertici V, Dousset E, Marqueste T, Decherchi P
Aix-Marseille Université, CNRS, ISM UMR 7287, 13288, Marseille, France.
Aix-Marseille Université, CNRS, ISM UMR 7287, 13288, Marseille, France.
Neuroscience. 2015 Apr 2;290:543-51. doi: 10.1016/j.neuroscience.2015.01.065. Epub 2015 Feb 7.
The present review is focused on neural mechanisms responsible of group III and IV muscle afferent actions on central motor drive during physical exercise in both healthy and pathological populations. It seems that these mechanisms contribute to improve muscle performance by regulating the peripheral fatigue development and by avoiding excessive muscle impairments. Therefore, a great deal of attention is paid to their influences on motor unit activation during fatiguing exercise both in human and animal models. Recent evidence indicated that these afferents from a given active muscle could contribute to regulate the motor activity of the homonymous as well as surrounding skeletal muscles by acting at both spinal and supraspinal levels. In addition, given that the recovery of the sensory feedback plays a key role in the improvement of motor function following numerous neuromuscular traumas, the role of these afferents in preclinical and clinical situations is also explored in animal and human models. It is supposed that studying the motor and autonomic functions of group III and IV afferents might help healthcare professionals in the future to find appropriate treatments and rehabilitation programs.
本综述聚焦于在健康人群和患病人群进行体育锻炼期间，Ⅲ类和Ⅳ类肌肉传入神经对中枢运动驱动作用的神经机制。这些机制似乎通过调节外周疲劳发展和避免过度的肌肉损伤来有助于改善肌肉性能。因此，无论是在人体模型还是动物模型中，人们都高度关注它们在疲劳运动期间对运动单位激活的影响。最近的证据表明，来自特定活动肌肉的这些传入神经可通过在脊髓和脊髓上水平发挥作用，来调节同名以及周围骨骼肌的运动活动。此外，鉴于感觉反馈的恢复在众多神经肌肉创伤后运动功能改善中起关键作用，在动物和人体模型中也探讨了这些传入神经在临床前和临床情况下的作用。据推测，研究Ⅲ类和Ⅳ类传入神经的运动和自主功能可能有助于未来的医疗保健专业人员找到合适的治疗方法和康复方案。
