肾移植患者体内的抗肌钙蛋白I抗体。
Anti-troponin I antibodies in renal transplant patients.
作者信息
Nunes José Pedro L, Sampaio Susana, Cerqueira Ana, Kaya Ziya, Oliveira Nuno Pardal
机构信息
Faculdade de Medicina da Universidade do Porto, Portugal; Department of Cardiology, Hospital São João, Porto, Portugal.
Faculdade de Medicina da Universidade do Porto, Portugal; Department of Nephrology, Hospital São João, Porto, Portugal.
出版信息
Rev Port Cardiol. 2015 Feb;34(2):85-9. doi: 10.1016/j.repc.2014.08.018. Epub 2015 Feb 3.
OBJECTIVE
To characterize the prevalence and clinical correlates of anti-troponin I antibodies in renal transplant patients.
METHODS
A group of 48 consecutive renal transplant patients under immunosuppressive therapy were studied. Anti-troponin I antibodies were measured and clinical data were retrieved.
RESULTS
An anti-troponin I antibody titer <1:40 was seen in most patients (30). IgG antibody titers ≥1:80 were seen in eight patients, with a single value of 1:160. Regarding IgM antibodies, in six cases titers ≥1:80 were seen, with one value of 1:320. In only one patient were both anti-troponin I antibody IgG and IgM titers 1:80 or higher. Clinical cardiac disease was seen in nine patients. The presence of an anti-troponin I antibody titer ≥1:80 was not associated with the presence of clinical cardiac disease (p=0.232), but was associated with statin therapy status (p=0.008), being less frequent in patients under statin therapy.
CONCLUSIONS
Anti-troponin I antibodies are seen in a minority of renal transplant patients, and are not associated with the presence of clinical heart disease, but are associated with lack of statin therapy.
目的
描述肾移植患者中抗肌钙蛋白I抗体的患病率及其临床相关性。
方法
对一组48例接受免疫抑制治疗的连续肾移植患者进行研究。检测抗肌钙蛋白I抗体，并收集临床数据。
结果
大多数患者（30例）的抗肌钙蛋白I抗体滴度<1:40。8例患者的IgG抗体滴度≥1:80，其中1例为1:160。关于IgM抗体，6例患者的滴度≥1:80，其中1例为1:320。仅1例患者的抗肌钙蛋白I抗体IgG和IgM滴度均为1:80或更高。9例患者出现临床心脏病。抗肌钙蛋白I抗体滴度≥1:80与临床心脏病的存在无关（p = 0.232），但与他汀类药物治疗状态有关（p = 0.008），在接受他汀类药物治疗的患者中较少见。
结论
少数肾移植患者中可检测到抗肌钙蛋白I抗体，其与临床心脏病的存在无关，但与未接受他汀类药物治疗有关。
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