Wang Wei, Dong Li-Ping, Zhang Ning, Zhao Cheng-Hai
Department of Pathophysiology, College of Basic Medical Science, China Medical University Shenyang 110001, P.R. China.
Library of China Medical University Shenyang 110001, P.R. China.
Int J Clin Exp Med. 2014 Dec 15;7(12):5059-66. eCollection 2014.
Cluster of differentiation 44 (CD44), a principal cell surface receptor for hyaluronic acid, has been implicated in tumorigenesis and metastasis. However, the relationship between CD44 expression and the patients with gastric cancer remains controversial. A meta-analysis was performed to quantitatively review the correlation of CD44 expression with the clinicopathological data of the patients with gastric cancer. We conducted a final analysis of the patients from 18 studies. Combined odds ratios (OR) suggested that CD44 expression was related with stage, tumor size, and LN metastasis of gastric cancer, and CD44v6 was related with LN metastasis, lymphatic invasion, and venous invasion. Our results suggested that CD44 and CD44v6 expression could be used to predict the metastasis of gastric cancer.
分化簇44（CD44）是透明质酸的主要细胞表面受体，与肿瘤发生和转移有关。然而，CD44表达与胃癌患者之间的关系仍存在争议。进行了一项荟萃分析，以定量综述CD44表达与胃癌患者临床病理数据的相关性。我们对18项研究中的患者进行了最终分析。合并比值比（OR）表明，CD44表达与胃癌的分期、肿瘤大小和淋巴结转移有关，而CD44v6与淋巴结转移、淋巴管侵犯和静脉侵犯有关。我们的结果表明，CD44和CD44v6表达可用于预测胃癌的转移。
