癌症干细胞标志物CD44在胃癌中的作用：一项荟萃分析。
Role of cancer stem cell marker CD44 in gastric cancer: a meta-analysis.
作者信息
Wang Wei, Dong Li-Ping, Zhang Ning, Zhao Cheng-Hai
机构信息
Department of Pathophysiology, College of Basic Medical Science, China Medical University Shenyang 110001, P.R. China.
Library of China Medical University Shenyang 110001, P.R. China.
出版信息
Int J Clin Exp Med. 2014 Dec 15;7(12):5059-66. eCollection 2014.
Abstract
Cluster of differentiation 44 (CD44), a principal cell surface receptor for hyaluronic acid, has been implicated in tumorigenesis and metastasis. However, the relationship between CD44 expression and the patients with gastric cancer remains controversial. A meta-analysis was performed to quantitatively review the correlation of CD44 expression with the clinicopathological data of the patients with gastric cancer. We conducted a final analysis of the patients from 18 studies. Combined odds ratios (OR) suggested that CD44 expression was related with stage, tumor size, and LN metastasis of gastric cancer, and CD44v6 was related with LN metastasis, lymphatic invasion, and venous invasion. Our results suggested that CD44 and CD44v6 expression could be used to predict the metastasis of gastric cancer.
摘要
分化簇44（CD44）是透明质酸的主要细胞表面受体，与肿瘤发生和转移有关。然而，CD44表达与胃癌患者之间的关系仍存在争议。进行了一项荟萃分析，以定量综述CD44表达与胃癌患者临床病理数据的相关性。我们对18项研究中的患者进行了最终分析。合并比值比（OR）表明，CD44表达与胃癌的分期、肿瘤大小和淋巴结转移有关，而CD44v6与淋巴结转移、淋巴管侵犯和静脉侵犯有关。我们的结果表明，CD44和CD44v6表达可用于预测胃癌的转移。
相似文献
1
Role of cancer stem cell marker CD44 in gastric cancer: a meta-analysis.癌症干细胞标志物CD44在胃癌中的作用：一项荟萃分析。
Int J Clin Exp Med. 2014 Dec 15;7(12):5059-66. eCollection 2014.
2
[Expression tumor stem cell surface marker CD44 in gastric cancer and its significance].[肿瘤干细胞表面标志物CD44在胃癌中的表达及其意义]
Zhonghua Wei Chang Wai Ke Za Zhi. 2013 Nov;16(11):1107-12.
3
CD44 and CD44v6 are Correlated with Gastric Cancer Progression and Poor Patient Prognosis: Evidence from 42 Studies.CD44和CD44v6与胃癌进展及患者预后不良相关：来自42项研究的证据。
Cell Physiol Biochem. 2016;40(3-4):567-578. doi: 10.1159/000452570. Epub 2016 Nov 25.
4
The prognostic value of CD44 expression in gastric cancer: a meta-analysis.CD44表达在胃癌中的预后价值：一项荟萃分析。
Biomed Pharmacother. 2014 Jul;68(6):693-7. doi: 10.1016/j.biopha.2014.08.001. Epub 2014 Aug 14.
5
The Prognostic and Clinical Value of CD44 in Colorectal Cancer: A Meta-Analysis.CD44在结直肠癌中的预后及临床价值：一项荟萃分析
Front Oncol. 2019 Apr 30;9:309. doi: 10.3389/fonc.2019.00309. eCollection 2019.
6
Nomogram Incorporating CD44v6 and Clinicopathological Factors to Predict Lymph Node Metastasis for Early Gastric Cancer.纳入CD44v6和临床病理因素的列线图预测早期胃癌淋巴结转移
PLoS One. 2016 Aug 2;11(8):e0159424. doi: 10.1371/journal.pone.0159424. eCollection 2016.
7
Prognostic value of CD44 variant exon 6 expression in non-small cell lung cancer: a meta-analysis.CD44变异外显子6表达在非小细胞肺癌中的预后价值：一项Meta分析
Asian Pac J Cancer Prev. 2014;15(16):6761-6. doi: 10.7314/apjcp.2014.15.16.6761.
8
Evaluation of the prognostic value and functional roles of CD44v6 in gastric cancer.CD44v6在胃癌中的预后价值及功能作用评估。
J Cancer Res Clin Oncol. 2015 Oct;141(10):1809-17. doi: 10.1007/s00432-015-1964-8. Epub 2015 Mar 26.
9
CD44v6 expression in patients with stage II or stage III sporadic colorectal cancer is superior to CD44 expression for predicting progression.在预测II期或III期散发性结直肠癌患者病情进展方面，CD44v6表达优于CD44表达。
Int J Clin Exp Pathol. 2015 Jan 1;8(1):692-701. eCollection 2015.
10
The prognostic role of the cancer stem cell marker CD44 in ovarian cancer: a meta-analysis.癌症干细胞标志物CD44在卵巢癌中的预后作用：一项荟萃分析。
Cancer Cell Int. 2017 Jan 5;17:8. doi: 10.1186/s12935-016-0376-4. eCollection 2017.
引用本文的文献
1
Spatially Resolved Tumor Ecosystems and Cell States in Gastric Adenocarcinoma Progression and Evolution.胃腺癌进展与演变中的空间分辨肿瘤生态系统和细胞状态
Cancer Discov. 2025 Apr 2;15(4):767-792. doi: 10.1158/2159-8290.CD-24-0605.
2
MicroRNA-98 as a novel diagnostic marker and therapeutic target in cancer patients.微小RNA-98作为癌症患者的一种新型诊断标志物和治疗靶点。
Discov Oncol. 2024 Aug 29;15(1):385. doi: 10.1007/s12672-024-01270-z.
3
Hub genes and pathways in gastric cancer: A comparison between studies that used normal tissues adjacent to the tumour and studies that used healthy tissues as calibrator.胃癌的枢纽基因和通路：使用肿瘤旁正常组织与使用健康组织作为校准物的研究之间的比较。
IET Syst Biol. 2023 Jun;17(3):131-141. doi: 10.1049/syb2.12065. Epub 2023 Apr 29.
4
Expression of CD44/CD24, RAD6 and DDB2 on chemotherapy response in ovarian Cancer: A prospective flow cytometry study.CD44/CD24、RAD6和DDB2表达对卵巢癌化疗反应的影响：一项前瞻性流式细胞术研究
Gynecol Oncol Rep. 2022 Jun 3;42:101005. doi: 10.1016/j.gore.2022.101005. eCollection 2022 Aug.
5
Vitamin D modulation and microRNAs in gastric cancer: prognostic and therapeutic role.维生素D调节与微小RNA在胃癌中的作用：预后及治疗意义
Transl Cancer Res. 2021 Jun;10(6):3111-3127. doi: 10.21037/tcr-20-2813.
6
A functional network of gastric-cancer-associated splicing events controlled by dysregulated splicing factors.由失调的剪接因子控制的胃癌相关剪接事件的功能网络。
NAR Genom Bioinform. 2020 Feb 28;2(2):lqaa013. doi: 10.1093/nargab/lqaa013. eCollection 2020 Jun.
7
Screening and identification of a CD44v6 specific peptide using improved phage display for gastric cancer targeting.利用改进的噬菌体展示技术筛选和鉴定用于靶向胃癌的CD44v6特异性肽。
Ann Transl Med. 2020 Nov;8(21):1442. doi: 10.21037/atm-19-4781.
8
Emerging Therapies in the Management of Advanced-Stage Gastric Cancer.晚期胃癌治疗中的新兴疗法
Front Pharmacol. 2018 Sep 13;9:404. doi: 10.3389/fphar.2018.00404. eCollection 2018.
9
CD44 cytokeratin-positive tumor cells in blood and bone marrow are associated with poor prognosis of patients with gastric cancer.血液和骨髓中 CD44 细胞角蛋白阳性的肿瘤细胞与胃癌患者的预后不良相关。
Gastric Cancer. 2019 Mar;22(2):264-272. doi: 10.1007/s10120-018-0858-2. Epub 2018 Jul 28.
10
Establishment and Characterization of a Highly Metastatic Ovarian Cancer Cell Line.建立并鉴定一个高转移性卵巢癌细胞系。
Biomed Res Int. 2018 Jun 25;2018:3972534. doi: 10.1155/2018/3972534. eCollection 2018.
本文引用的文献
1
Genetic association of osteopontin (OPN) and its receptor CD44 genes with susceptibility to Chinese gastric cancer patients.骨桥蛋白（OPN）及其受体CD44基因与中国胃癌患者易感性的遗传关联。
J Cancer Res Clin Oncol. 2014 Dec;140(12):2143-56. doi: 10.1007/s00432-014-1761-9. Epub 2014 Jul 10.
2
Stem cell-like circulating tumor cells indicate poor prognosis in gastric cancer.干细胞样循环肿瘤细胞提示胃癌预后不良。
Biomed Res Int. 2014;2014:981261. doi: 10.1155/2014/981261. Epub 2014 May 22.
3
CD44(+) CD324(-) expression and prognosis in gastric cancer patients.CD44(+) CD324(-)表达与胃癌患者的预后
J Surg Oncol. 2014 Nov;110(6):727-33. doi: 10.1002/jso.23690. Epub 2014 Jun 9.
4
Gastric cancer stem cells in gastric carcinogenesis, progression, prevention and treatment.胃癌干细胞在胃癌发生、发展、预防及治疗中的作用
World J Gastroenterol. 2014 May 14;20(18):5420-6. doi: 10.3748/wjg.v20.i18.5420.
5
Clinicopathologic significance of putative stem cell marker, CD44 and CD133, in human gastric carcinoma.人胃癌中假定干细胞标志物 CD44 和 CD133 的临床病理意义。
J Surg Oncol. 2013 Jun;107(8):799-806. doi: 10.1002/jso.23337. Epub 2013 Apr 22.
6
Expression of CD44v6 and Livin in gastric cancer tissue.胃癌组织中 CD44v6 和 Livin 的表达。
Chin Med J (Engl). 2012 Sep;125(17):3161-5.
7
Expression of cancer stem cell markers ALDH1, CD44 and CD133 in primary tumor and lymph node metastasis of gastric cancer.胃癌原发灶及淋巴结转移组织中肿瘤干细胞标志物 ALDH1、CD44 和 CD133 的表达。
Pathol Int. 2012 Feb;62(2):112-9. doi: 10.1111/j.1440-1827.2011.02760.x. Epub 2011 Nov 30.
8
Clinical significance of intraperitoneal CD44 mRNA levels of magnetically separated CD45-negative EpCAM-positive cells for peritoneal recurrence and prognosis in stage II and III gastric cancer patients.磁分离 CD45 阴性 EpCAM 阳性细胞腹腔内 CD44mRNA 水平对 II 期和 III 期胃癌患者腹腔复发和预后的临床意义。
Oncol Rep. 2011 May;25(5):1413-20. doi: 10.3892/or.2011.1191. Epub 2011 Feb 18.
9
Global cancer statistics.全球癌症统计数据。
CA Cancer J Clin. 2011 Mar-Apr;61(2):69-90. doi: 10.3322/caac.20107. Epub 2011 Feb 4.
10
De novo expression of CD44 variants in sporadic and hereditary gastric cancer.散发性和遗传性胃癌中 CD44 变体的从头表达。
Lab Invest. 2010 Nov;90(11):1604-14. doi: 10.1038/labinvest.2010.155. Epub 2010 Sep 20.
Zotero 插件