Yu Zhiliang, Qin Wangrong, Lin Jianxun, Fang Shisong, Qiu Juanping
College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou 310014, China.
Department of Electrical Engineering, Columbia University, New York City, NY 10027, USA.
Biomed Res Int. 2015;2015:679109. doi: 10.1155/2015/679109. Epub 2015 Jan 15.
Multidrug resistance in pathogens is an increasingly significant threat for human health. Indeed, some strains are resistant to almost all currently available antibiotics, leaving very limited choices for antimicrobial clinical therapy. In many such cases, polymyxins are the last option available, although their use increases the risk of developing resistant strains. This review mainly aims to discuss advances in unraveling the mechanisms of antibacterial activity of polymyxins and bacterial tolerance together with the description of polymyxin structure, synthesis, and structural modification. These are expected to help researchers not only develop a series of new polymyxin derivatives necessary for future medical care, but also optimize the clinical use of polymyxins with minimal resistance development.
病原体中的多重耐药性对人类健康构成了日益严重的威胁。事实上，一些菌株对几乎所有目前可用的抗生素都具有抗性，这使得抗菌临床治疗的选择非常有限。在许多此类情况下，多粘菌素是最后的可用选择，尽管使用它们会增加产生耐药菌株的风险。本综述主要旨在讨论在阐明多粘菌素抗菌活性机制和细菌耐受性方面的进展，同时描述多粘菌素的结构、合成及结构修饰。这些有望帮助研究人员不仅开发出未来医疗所需的一系列新型多粘菌素衍生物，还能在最小化耐药性产生的情况下优化多粘菌素的临床应用。
