持续和间歇性喂食克伦特罗对大鼠生长速率和肌肉的影响。
Effect of continuous and intermittent clenbuterol feeding on rat growth rate and muscle.
作者信息
McElligott M A, Barreto A, Chaung L Y
机构信息
Merck Sharp & Dohme Research Laboratories, Department of Physiology and Biochemistry, Rahway, NJ 07065.
出版信息
Comp Biochem Physiol C Comp Pharmacol Toxicol. 1989;92(1):135-8. doi: 10.1016/0742-8413(89)90215-6.
PMID:2566434
Abstract
- The growth response to clenbuterol is a dynamic process. 2. Body weight gain is stimulated within two days of treatment and the effect attenuates by two weeks of treatment. 3. Intermittent feeding prevents the attenuation of the growth response. 4. Muscle weight increased 14-22% by both feeding regimens. 5. Clenbuterol decreased cathepsin B activity in the EDL and gastrocnemius and increased the activity in the soleus after two weeks of continuous clenbuterol treatment.
摘要
- 对克伦特罗的生长反应是一个动态过程。2. 治疗两天内体重增加受到刺激，而治疗两周后这种效果减弱。3. 间歇性喂食可防止生长反应减弱。4. 两种喂食方案均使肌肉重量增加了14% - 22%。5. 连续使用克伦特罗治疗两周后，克伦特罗降低了趾长伸肌和腓肠肌中的组织蛋白酶B活性，并增加了比目鱼肌中的该活性。
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