Rothwell N J, Stock M J
Biosci Rep. 1985 Sep;5(9):755-60. doi: 10.1007/BF01119873.
Female dystrophic mice (mdx on C57 Black background) gained weight more rapidly than age-matched controls and had a higher body fat content (% body weight), a slightly lower protein content and a reduced mass of muscle. Chronic treatment (21 d) of the mice with the beta 2-agonist clenbuterol stimulated weight gain in both genotypes without affecting energy intake. Clenbuterol increased the mass of the gastrocnemius and soleus muscle by 13% and 29% in normal and dystrophic mice, respectively, and raised body protein but depressed body fat. Body water and energy content were unaffected by clenbuterol, but the ratio of protein to fat in the carcasses was enhanced by 17% in normal and 56% in dystrophic mice following clenbuterol treatment. Thus, the beta 2-agonist restored the body composition of dystrophic mice to normal and enhanced the protein to fat ratio in both these and normal mice.
雌性营养不良小鼠（C57黑色背景的mdx小鼠）比年龄匹配的对照小鼠体重增加更快，体脂含量（占体重百分比）更高，蛋白质含量略低，肌肉质量减少。用β2激动剂克仑特罗对小鼠进行慢性治疗（21天）可刺激两种基因型小鼠体重增加，且不影响能量摄入。克仑特罗使正常小鼠和营养不良小鼠的腓肠肌和比目鱼肌质量分别增加了13%和29%，增加了身体蛋白质含量，但降低了体脂。克仑特罗对身体水分和能量含量没有影响，但在克仑特罗治疗后，正常小鼠和营养不良小鼠尸体中的蛋白质与脂肪比例分别提高了17%和56%。因此，β2激动剂使营养不良小鼠的身体组成恢复正常，并提高了这些小鼠和正常小鼠的蛋白质与脂肪比例。
