Schreier Wolfgang J, Gilch Peter, Zinth Wolfgang
Lehrstuhl für BioMolekulare Optik, Fakultät für Physik and Munich Center for Integrated Protein Science CIPSM, Ludwig-Maximilians-Universität München, 80538 München, Germany; email:
Annu Rev Phys Chem. 2015 Apr;66:497-519. doi: 10.1146/annurev-physchem-040214-121821. Epub 2015 Feb 6.
Ultraviolet (UV) radiation is a leading external hazard to the integrity of DNA. Exposure to UV radiation triggers a cascade of chemical reactions, and many molecular products (photolesions) have been isolated that are potentially dangerous for the cellular system. The early steps that take place after UV absorption by DNA have been studied by ultrafast spectroscopy. The review focuses on the evolution of excited electronic states, the formation of photolesions, and processes suppressing their formation. Emphasis is placed on lesions involving two thymine bases, such as the cyclobutane pyrimidine dimer, the (6-4) lesion, and its Dewar valence isomer.
紫外线（UV）辐射是对DNA完整性的主要外部危害。暴露于紫外线辐射会引发一系列化学反应，并且已经分离出许多对细胞系统有潜在危险的分子产物（光损伤）。通过超快光谱学研究了DNA吸收紫外线后发生的早期步骤。该综述重点关注激发电子态的演化、光损伤的形成以及抑制其形成的过程。重点是涉及两个胸腺嘧啶碱基的损伤，例如环丁烷嘧啶二聚体、（6-4）损伤及其杜瓦价异构体。
