Psichas Arianna, Reimann Frank, Gribble Fiona M
J Clin Invest. 2015 Mar 2;125(3):908-17. doi: 10.1172/JCI76309. Epub 2015 Feb 9.
The enteroendocrine system is the primary sensor of ingested nutrients and is responsible for secreting an array of gut hormones, which modulate multiple physiological responses including gastrointestinal motility and secretion, glucose homeostasis, and appetite. This Review provides an up-to-date synopsis of the molecular mechanisms underlying enteroendocrine nutrient sensing and highlights our current understanding of the neuro-hormonal regulation of gut hormone secretion, including the interaction between the enteroendocrine system and the enteric nervous system. It is hoped that a deeper understanding of how these systems collectively regulate postprandial physiology will further facilitate the development of novel therapeutic strategies.
肠内分泌系统是摄入营养物质的主要传感器，负责分泌一系列肠道激素，这些激素调节多种生理反应，包括胃肠蠕动和分泌、葡萄糖稳态及食欲。本综述提供了肠内分泌营养感知潜在分子机制的最新概述，并着重介绍了我们目前对肠道激素分泌的神经激素调节的理解，包括肠内分泌系统与肠神经系统之间的相互作用。希望对这些系统如何共同调节餐后生理的更深入理解将进一步促进新型治疗策略的开发。
