Gribble Fiona M, Reimann Frank
Metabolic Research Laboratories and MRC Metabolic Diseases Unit, Wellcome Trust-MRC Institute of Metabolic Science, and Addenbrooke's Hospital, University of Cambridge, Cambridge CB2 0QQ, United Kingdom; email:
Annu Rev Physiol. 2016;78:277-99. doi: 10.1146/annurev-physiol-021115-105439. Epub 2015 Oct 6.
The enteroendocrine system orchestrates how the body responds to the ingestion of foods, employing a diversity of hormones to fine-tune a wide range of physiological responses both within and outside the gut. Recent interest in gut hormones has surged with the realization that they modulate glucose tolerance and food intake through a variety of mechanisms, and such hormones are therefore excellent therapeutic candidates for the treatment of diabetes and obesity. Characterizing the roles and functions of different enteroendocrine cells is an essential step in understanding the physiology, pathophysiology, and therapeutics of the gut-brain-pancreas axis.
肠内分泌系统协调身体对食物摄入的反应，利用多种激素来微调肠道内外的一系列生理反应。随着人们认识到肠道激素通过多种机制调节葡萄糖耐量和食物摄入，近期对肠道激素的兴趣激增，因此这类激素是治疗糖尿病和肥胖症的理想候选药物。明确不同肠内分泌细胞的作用和功能是理解肠-脑-胰腺轴的生理学、病理生理学和治疗学的关键一步。
