从硫磺多孔菌培养物中分离得到的七种新的杜松烷型倍半萜类化合物。
Seven new drimane-type sesquiterpenoids from cultures of fungus Laetiporus sulphureus.
作者信息
He Jiang-Bo, Tao Jian, Miao Xi-Song, Bu Wei, Zhang Shen, Dong Ze-Jun, Li Zheng-Hui, Feng Tao, Liu Ji-Kai
机构信息
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Instituent of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China; School of Medicine, Kunming University, Kunming 650214, People's Republic of China.
School of Medicine, Kunming University, Kunming 650214, People's Republic of China.
出版信息
Fitoterapia. 2015 Apr;102:1-6. doi: 10.1016/j.fitote.2015.01.022. Epub 2015 Feb 7.
Seven new drimane-type sesquiterpenoids, sulphureuines B-H (1-7), together with four known compounds (8-11), were obtained from cultures of mushroom Laetiporus sulphureus. All of these compounds were tested for their cytotoxicities against five human cancer cell lines (HL-60, SMMC-721, A-549, MCF-7, SW-480), compound 10 showed potent cytotoxic activity against HL-60, SMMC-721, A-549, SW-480, with IC50 values of 37.5, 14.8, 15.6, and 36.1μM, respectively.
从硫黄多孔菌的培养物中获得了7种新的菖蒲烷型倍半萜类化合物，即硫黄菌素B - H（1 - 7），以及4种已知化合物（8 - 11）。对所有这些化合物针对5种人类癌细胞系（HL - 60、SMMC - 721、A - 549、MCF - 7、SW - 480）进行了细胞毒性测试，化合物10对HL - 60、SMMC - 721、A - 549、SW - 480显示出较强的细胞毒性活性，IC50值分别为37.5、14.8、15.6和36.1μM。
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