Krämer A, Wiktor S Z, Fuchs D, Milstien S, Gail M H, Yellin F J, Biggar R J, Wachter H, Kaufman S, Blattner W A
National Cancer Institute, Rockville, MD 20852.
J Acquir Immune Defic Syndr (1988). 1989;2(3):291-6.
In 79 homosexual men infected with human immunodeficiency virus (HIV), urinary neopterin was significantly higher as compared with 70 HIV-seronegative men in the same cohort (p less than 0.0001). This highly significant association was found both for naturally occurring oxidized (native) neopterin and for total neopterin (native plus chemically oxidized forms). In prospective follow-up for 18 months, the odds that the acquired immune deficiency syndrome (AIDS) would develop were elevated 25-fold among those whose native neopterin levels were in the highest quartile compared with those with lower neopterin levels, and the corresponding odds ratio for total neopterin was 7.8. Logistic regression analyses indicated that neopterin added useful information to T4-cell count in predicting AIDS onset and that both are statistically significant in the multivariate model. A cross-sectional survey revealed that neopterin levels were correlated with number of receptive anal intercourse partners in the year before HIV seroconversion (r = 0.60, p = 0.0005). Since neopterin may serve as a marker of monocyte/macrophage activation by soluble factors such as gamma-interferon, these data support a growing body of virologic and immunologic evidence that highlights the important role of the monocyte/macrophage in the pathogenesis of AIDS.
在79名感染人类免疫缺陷病毒（HIV）的同性恋男性中，尿新蝶呤水平显著高于同一队列中的70名HIV血清阴性男性（p<0.0001）。对于天然存在的氧化型（天然）新蝶呤和总新蝶呤（天然型加化学氧化型），均发现了这种高度显著的关联。在为期18个月的前瞻性随访中，与新蝶呤水平较低者相比，天然新蝶呤水平处于最高四分位数者发生获得性免疫缺陷综合征（AIDS）的几率升高了25倍，总新蝶呤的相应比值比为7.8。逻辑回归分析表明，新蝶呤在预测AIDS发病方面为T4细胞计数增加了有用信息，且在多变量模型中两者均具有统计学意义。一项横断面调查显示，新蝶呤水平与HIV血清转化前一年中接受肛交性伴侣的数量相关（r = 0.60，p = 0.0005）。由于新蝶呤可能作为可溶性因子（如γ干扰素）激活单核细胞/巨噬细胞的标志物，这些数据支持了越来越多的病毒学和免疫学证据，突出了单核细胞/巨噬细胞在AIDS发病机制中的重要作用。
