糖尿病性胃轻瘫
Diabetic gastroparesis.
作者信息
Koch Kenneth L, Calles-Escandón Jorge
机构信息
Section on Gastroenterology, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157, USA.
Section on Endocrinology, MetroHealth Regional, Case Western Reserve University School of Medicine, 2500 Metrohealth Drive, Cleveland, OH 44109, USA.
出版信息
Gastroenterol Clin North Am. 2015 Mar;44(1):39-57. doi: 10.1016/j.gtc.2014.11.005.
Gastroparesis is a complication of long-standing type 1 and type 2 diabetes mellitus. Symptoms associated with gastroparesis include early satiety, prolonged postprandial fullness, bloating, nausea and vomiting, and abdominal pain. Mortality is increased in patients with diabetic gastroparesis. A subset of patients with diabetic gastroparesis have pylorospasm that results in obstructive gastroparesis. Current treatment approaches include improving glucose control with insulin and prescribing antinauseant drugs, prokinetic agents, and gastric electric stimulation. Future directions include improved diet counseling based on gastric emptying rate, continuous insulin delivery systems with glucose sensor-augmented monitoring, and drugs for correcting gastric neural and electric abnormalities.
胃轻瘫是1型和2型糖尿病的一种长期并发症。与胃轻瘫相关的症状包括早饱、餐后饱腹感延长、腹胀、恶心和呕吐以及腹痛。糖尿病胃轻瘫患者的死亡率会增加。一部分糖尿病胃轻瘫患者存在幽门痉挛,导致梗阻性胃轻瘫。目前的治疗方法包括使用胰岛素改善血糖控制以及开具止吐药、促动力药和胃电刺激治疗。未来的发展方向包括基于胃排空率改进饮食咨询、具有葡萄糖传感器增强监测功能的持续胰岛素输注系统以及纠正胃神经和电异常的药物。