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Non-invasive neuromodulation: an emerging intervention for visceral pain in gastrointestinal disorders.

作者信息

Alam Md Jahangir, Chen Jiande D Z

机构信息

Division of Gastroenterology and Hepatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, 48109, USA.

出版信息

Bioelectron Med. 2023 Nov 22;9(1):27. doi: 10.1186/s42234-023-00130-5.


DOI:10.1186/s42234-023-00130-5
PMID:37990288
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10664460/
Abstract

Gastrointestinal (GI) disorders, which extend from the esophagus to the anus, are the most common diseases of the GI tract. Among these disorders, pain, encompassing both abdominal and visceral pain, is a predominant feature, affecting the patients' quality of life and imposing a substantial financial burden on society. Pain signals originating from the gut intricately shape brain dynamics. In response, the brain sends appropriate descending signals to respond to pain through neuronal inhibition. However, due to the heterogeneous nature of the disease and its limited pathophysiological understanding, treatment options are minimal and often controversial. Consequently, many patients with GI disorders use complementary and alternative therapies such as neuromodulation to treat visceral pain. Neuromodulation intervenes in the central, peripheral, or autonomic nervous system by alternating or modulating nerve activity using electrical, electromagnetic, chemical, or optogenetic methodologies. Here, we review a few emerging noninvasive neuromodulation approaches with promising potential for alleviating pain associated with functional dyspepsia, gastroparesis, irritable bowel syndrome, inflammatory bowel disease, and non-cardiac chest pain. Moreover, we address critical aspects, including the efficacy, safety, and feasibility of these noninvasive neuromodulation methods, elucidate their mechanisms of action, and outline future research directions. In conclusion, the emerging field of noninvasive neuromodulation appears as a viable alternative therapeutic avenue for effectively managing visceral pain in GI disorders.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f268/10664460/5c0b846f82e6/42234_2023_130_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f268/10664460/5c0b846f82e6/42234_2023_130_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f268/10664460/5c0b846f82e6/42234_2023_130_Fig1_HTML.jpg

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Non-invasive neuromodulation: an emerging intervention for visceral pain in gastrointestinal disorders.

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[7]
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[9]
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[4]
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[5]
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[6]
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[8]
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[9]
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本文引用的文献

[1]
Transcutaneous auricular vagus nerve stimulation attenuates inflammatory bowel disease in children: a proof-of-concept clinical trial.

Bioelectron Med. 2023-10-18

[2]
Transcutaneous Auricular Vagal Nerve Stimulation Is Effective for the Treatment of Functional Dyspepsia: A Multicenter, Randomized Controlled Study.

Am J Gastroenterol. 2024-3-1

[3]
Gastric vagal afferent signaling to the basolateral amygdala mediates anxiety-like behaviors in experimental colitis mice.

JCI Insight. 2023-6-22

[4]
Effect and mechanism of acupuncture on Alzheimer's disease: A review.

Front Aging Neurosci. 2023-3-3

[5]
Electrophysiology as a Tool to Decipher the Network Mechanism of Visceral Pain in Functional Gastrointestinal Disorders.

Diagnostics (Basel). 2023-2-8

[6]
The neurobiology of irritable bowel syndrome.

Mol Psychiatry. 2023-4

[7]
Acupuncture for the Treatment of Diarrhea-Predominant Irritable Bowel Syndrome: A Pilot Randomized Clinical Trial.

JAMA Netw Open. 2022-12-1

[8]
Targeting cytokines in inflammatory bowel disease.

Sci Transl Med. 2022-12-14

[9]
Effects of transcutaneous electrical acupoint stimulation on upper-limb impairment after stroke: A randomized, controlled, single-blind trial.

Clin Rehabil. 2023-5

[10]
Transcutaneous Electrical Acustimulation Improves Irritable Bowel Syndrome With Constipation by Accelerating Colon Transit and Reducing Rectal Sensation Using Autonomic Mechanisms.

Am J Gastroenterol. 2022-9-1

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