与海绵隐秘方板海绵相关的哈维氏弧菌菌株产生鞘氨醇。
Spongosine production by a Vibrio harveyi strain associated with the sponge Tectitethya crypta.
作者信息
Bertin Matthew J, Schwartz Sarah L, Lee John, Korobeynikov Anton, Dorrestein Pieter C, Gerwick Lena, Gerwick William H
机构信息
†Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California-San Diego, La Jolla, California 92037, United States.
§Environmental Systems Program, University of California-San Diego, La Jolla, California 92093, United States.
出版信息
J Nat Prod. 2015 Mar 27;78(3):493-9. doi: 10.1021/np5009762. Epub 2015 Feb 10.
Abstract
Spongosine (1), deoxyspongosine (2), spongothymidine (Ara T) (3), and spongouridine (Ara U) were isolated from the Caribbean sponge Tectitethya crypta and given the general name "spongonucleosides". Spongosine, a methoxyadenosine derivative, has demonstrated a diverse bioactivity profile including anti-inflammatory activity and analgesic and vasodilation properties. Investigations into unusual nucleoside production by T. crypta-associated microorganisms using mass spectrometric techniques have identified a spongosine-producing strain of Vibrio harveyi and several structurally related compounds from multiple strains.
摘要
从加勒比海绵隐板海绵（Tectitethya crypta）中分离出了鞘氨醇（1）、脱氧鞘氨醇（2）、海绵胸苷（阿糖胸苷）（3）和海绵尿苷（阿糖尿苷），它们被统称为“海绵核苷”。鞘氨醇是一种甲氧基腺苷衍生物，已显示出多种生物活性，包括抗炎活性、止痛和血管舒张特性。利用质谱技术对与隐板海绵相关的微生物产生的异常核苷进行的研究，已鉴定出一株能产生鞘氨醇的哈维氏弧菌菌株以及来自多个菌株的几种结构相关化合物。
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