空间视觉行为的光感受器调节
Photoreceptor regulation of spatial visual behavior.
作者信息
Alam Nazia M, Altimus Cara M, Douglas Robert M, Hattar Samer, Prusky Glen T
机构信息
Department of Physiology and Biophysics, Weill Medical College of Cornell University, New York, New York, United States Burke Medical Research Institute, White Plains, New York, United States.
Department of Biology, Johns Hopkins University, Baltimore, Maryland, United States.
出版信息
Invest Ophthalmol Vis Sci. 2015 Feb 10;56(3):1842-9. doi: 10.1167/iovs.14-15644.
PURPOSE
To better understand how photoreceptors and their circuits support luminance-dependent spatial visual behavior.
METHODS
Grating thresholds for optokinetic tracking were measured under defined luminance conditions in mice with genetic alterations of photoreceptor activity.
RESULTS
The luminance conditions that enable cone- and rod-mediated behavior, and the luminance range over which rod and cone functions overlap, were characterized. The AII amacrine pathway was found to support low-resolution and high-contrast function, with the rod-cone pathway supporting high-resolution and low-contrast function. Rods alone were also shown to be capable of driving cone-like spatial visual function, but only when cones were genetically maintained in a physiological dark state.
CONCLUSIONS
The study defined how luminance signals drive rod- and cone-mediated spatial visual behavior and revealed new and unexpected contributions for rods that depend on an interaction between cone and rod systems.
目的
为了更好地理解光感受器及其神经回路如何支持依赖亮度的空间视觉行为。
方法
在具有光感受器活性基因改变的小鼠中，于特定亮度条件下测量视动跟踪的光栅阈值。
结果
确定了使视锥和视杆介导的行为得以实现的亮度条件，以及视杆和视锥功能重叠的亮度范围。发现AII无长突细胞通路支持低分辨率和高对比度功能，而视杆 - 视锥通路支持高分辨率和低对比度功能。还表明仅视杆就能驱动类似视锥的空间视觉功能，但前提是视锥通过基因手段维持在生理暗状态。
结论
该研究明确了亮度信号如何驱动视杆和视锥介导的空间视觉行为，并揭示了视杆依赖视锥和视杆系统之间相互作用的新的意外贡献。
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