哪些人口统计学变量需要在研究血清素转运体可用性的神经影像学研究中进行校正？一项使用 [¹²³I]ADAM 的 SPECT 研究。
Which demographic variables are necessary to correct in neuroimaging studies of serotonin transporter availability? A SPECT study with [¹²³I]ADAM.
机构信息
Department of Psychiatry, National Cheng Kung University Hospital, Dou-Liou Branch, Yunlin, Taiwan; Department of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Department of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
出版信息
Psychiatry Res. 2015 Mar 30;231(3):320-4. doi: 10.1016/j.pscychresns.2015.01.015. Epub 2015 Jan 24.
Previous studies have shown that many demographic variables influence serotonin transporter (SERT) availability as assessed by single photon emission computed tomography (SPECT). The aim of this study was to explore which demographic variables influenced the SERT availability most in a SPECT study with [(123)I]ADAM. Ninety-five healthy volunteers were recruited. Age, sex, smoking, alcohol intake, educational level, body mass index, seasonal change, and SERT availability were recorded and then analyzed by multivariate linear regression. Age was the only variable that was significantly associated with SERT availability (calculate: (midbrain-cerebellum)/cerebellum). Furthermore, the inverse correlation of age and SERT availability may be present only before the age of 47. Age should be a covariate in SERT-related neuroimaging analyses, particularly in participants under the age of 47 years.
先前的研究表明，许多人口统计学变量会影响单光子发射计算机断层扫描（SPECT）评估的血清素转运体（SERT）可用性。本研究的目的是探索哪些人口统计学变量在使用 [(123)I]ADAM 的 SPECT 研究中对 SERT 可用性的影响最大。招募了 95 名健康志愿者。记录了年龄、性别、吸烟、饮酒、教育水平、体重指数、季节性变化和 SERT 可用性，并通过多元线性回归进行了分析。年龄是唯一与 SERT 可用性显著相关的变量（计算：（中脑-小脑）/小脑）。此外，年龄与 SERT 可用性的负相关关系可能仅在 47 岁之前存在。年龄应该是 SERT 相关神经影像学分析中的协变量，特别是在 47 岁以下的参与者中。
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