生酮饮食对缺血性中风所致神经元损伤具有神经保护作用。
Ketogenic Diet Provides Neuroprotective Effects against Ischemic Stroke Neuronal Damages.
作者信息
Shaafi Sheyda, Mahmoudi Javad, Pashapour Ali, Farhoudi Mehdi, Sadigh-Eteghad Saeed, Akbari Hossein
机构信息
Neurosciences Research Center (NSRC), Tabriz University of Medical Sciences, Tabriz, Iran.
出版信息
Adv Pharm Bull. 2014 Dec;4(Suppl 2):479-81. doi: 10.5681/apb.2014.071. Epub 2014 Dec 31.
Abstract
Ischemic stroke is a leading cause of death and disability in the world. Many mechanisms contribute in cell death in ischemic stroke. Ketogenic diet which has been successfully used in the drug-resistant epilepsy has been shown to be effective in many other neurologic disorders. The mechanisms underlying of its effects are not well studied, but it seems that its neuroprotective ability is mediated at least through alleviation of excitotoxicity, oxidative stress and apoptosis events. On the basis of these mechanisms, it is postulated that ketogenic diet could provide benefits to treatment of cerebral ischemic injuries.
摘要
缺血性中风是全球死亡和残疾的主要原因。许多机制导致缺血性中风中的细胞死亡。生酮饮食已成功用于治疗耐药性癫痫，在许多其他神经系统疾病中也显示出疗效。其作用的潜在机制尚未得到充分研究，但似乎其神经保护能力至少通过减轻兴奋性毒性、氧化应激和细胞凋亡事件来介导。基于这些机制，推测生酮饮食可能对治疗脑缺血损伤有益。
相似文献
1
Ketogenic Diet Provides Neuroprotective Effects against Ischemic Stroke Neuronal Damages.
Adv Pharm Bull. 2014 Dec;4(Suppl 2):479-81. doi: 10.5681/apb.2014.071. Epub 2014 Dec 31.
2
Early Motor-Behavioral Outcome of Ischemic Stroke with Ketogenic Diet Preconditioning: Interventional Animal Study.
J Stroke Cerebrovasc Dis. 2019 Apr;28(4):1032-1039. doi: 10.1016/j.jstrokecerebrovasdis.2018.12.024. Epub 2019 Jan 16.
3
The use of ketogenic diet in special situations: expanding use in intractable epilepsy and other neurologic disorders.
Korean J Pediatr. 2012 Sep;55(9):316-21. doi: 10.3345/kjp.2012.55.9.316. Epub 2012 Sep 14.
4
Potential Neuroprotective Treatment of Stroke: Targeting Excitotoxicity, Oxidative Stress, and Inflammation.
Front Neurosci. 2019 Sep 27;13:1036. doi: 10.3389/fnins.2019.01036. eCollection 2019.
5
[Anticonvulsant and neuroprotective effects of the ketogenic diet].
Przegl Lek. 2010;67(3):205-12.
6
Neuroprotective and disease-modifying effects of the ketogenic diet.
Behav Pharmacol. 2006 Sep;17(5-6):431-9. doi: 10.1097/00008877-200609000-00009.
7
Pathogenic mechanisms following ischemic stroke.
Neurol Sci. 2017 Jul;38(7):1167-1186. doi: 10.1007/s10072-017-2938-1. Epub 2017 Apr 17.
8
The mechanism of taurine protection against endoplasmic reticulum stress in an animal stroke model of cerebral artery occlusion and stroke-related conditions in primary neuronal cell culture.
Adv Exp Med Biol. 2013;776:241-58. doi: 10.1007/978-1-4614-6093-0_23.
9
Polydatin Attenuates Neuronal Loss Reducing Neuroinflammation and Oxidative Stress in Rat MCAO Models.
Front Pharmacol. 2019 Jun 26;10:663. doi: 10.3389/fphar.2019.00663. eCollection 2019.
10
The Anticonvulsant Effects of Ketogenic Diet on Epileptic Seizures and Potential Mechanisms.
Curr Neuropharmacol. 2018;16(1):66-70. doi: 10.2174/1570159X15666170517153509.
引用本文的文献
1
Ketogenic diets therapy in the management of epileptic spasms syndrome.
Front Pediatr. 2024 Nov 6;12:1472982. doi: 10.3389/fped.2024.1472982. eCollection 2024.
2
Gut microbes in cerebrovascular diseases: Gut flora imbalance, potential impact mechanisms and promising treatment strategies.
Front Immunol. 2022 Oct 31;13:975921. doi: 10.3389/fimmu.2022.975921. eCollection 2022.
3
Nutritional Impact on Metabolic Homeostasis and Brain Health.
Front Neurosci. 2022 Jan 27;15:767405. doi: 10.3389/fnins.2021.767405. eCollection 2021.
4
The relation of etiology based on the 2017 ILAE classification to the effectiveness of the ketogenic diet in drug-resistant epilepsy in childhood.
Epilepsia. 2021 Nov;62(11):2814-2825. doi: 10.1111/epi.17052. Epub 2021 Aug 28.
5
Scientific evidence underlying contraindications to the ketogenic diet: An update.
Obes Rev. 2020 Oct;21(10):e13053. doi: 10.1111/obr.13053. Epub 2020 Jul 10.
6
Application of ketogenic diets for pediatric neurocritical care.
Biomed J. 2020 Jun;43(3):218-225. doi: 10.1016/j.bj.2020.02.002. Epub 2020 Jul 5.
7
Ketogenic Diet and Epilepsy.
Nutrients. 2019 Oct 18;11(10):2510. doi: 10.3390/nu11102510.
8
Testosterone May Hold Therapeutic Promise for the Treatment of Ischemic Stroke in Aging: A Closer Look at Laboratory Findings.
Adv Pharm Bull. 2019 Feb;9(1):48-55. doi: 10.15171/apb.2019.006. Epub 2018 Feb 21.
9
Photobiomodulation and Coenzyme Q Treatments Attenuate Cognitive Impairment Associated With Model of Transient Global Brain Ischemia in Artificially Aged Mice.
Front Cell Neurosci. 2019 Mar 19;13:74. doi: 10.3389/fncel.2019.00074. eCollection 2019.
10
Ketogenic Diet Improves Brain Ischemic Tolerance and Inhibits NLRP3 Inflammasome Activation by Preventing Drp1-Mediated Mitochondrial Fission and Endoplasmic Reticulum Stress.
Front Mol Neurosci. 2018 Mar 20;11:86. doi: 10.3389/fnmol.2018.00086. eCollection 2018.
本文引用的文献
1
Ketogenic diet improves forelimb motor function after spinal cord injury in rodents.
PLoS One. 2013 Nov 4;8(11):e78765. doi: 10.1371/journal.pone.0078765. eCollection 2013.
2
A ketogenic diet delays weight loss and does not impair working memory or motor function in the R6/2 1J mouse model of Huntington's disease.
Physiol Behav. 2011 Jul 6;103(5):501-7. doi: 10.1016/j.physbeh.2011.04.001. Epub 2011 Apr 9.
3
Pathophysiology, treatment, and animal and cellular models of human ischemic stroke.
Mol Neurodegener. 2011 Jan 25;6(1):11. doi: 10.1186/1750-1326-6-11.
4
Prevalence of stroke and associated risk factors in older adults in Havana City and Matanzas Provinces, Cuba (10/66 population-based study).
MEDICC Rev. 2010 Jul;12(3):20-6. doi: 10.37757/MR2010.V12.N3.6.
5
Ketogenic diet protects dopaminergic neurons against 6-OHDA neurotoxicity via up-regulating glutathione in a rat model of Parkinson's disease.
Brain Res. 2009 Aug 25;1286:25-31. doi: 10.1016/j.brainres.2009.06.060. Epub 2009 Jun 25.
6
Apoptotic mechanisms after cerebral ischemia.
Stroke. 2009 May;40(5):e331-9. doi: 10.1161/STROKEAHA.108.531632. Epub 2009 Jan 29.
7
Medium-chain triglyceride (MCT) ketogenic therapy.
Epilepsia. 2008 Nov;49 Suppl 8:33-6. doi: 10.1111/j.1528-1167.2008.01830.x.
8
The neuroprotective properties of calorie restriction, the ketogenic diet, and ketone bodies.
Brain Res Rev. 2009 Mar;59(2):293-315. doi: 10.1016/j.brainresrev.2008.09.002. Epub 2008 Sep 25.
9
The utility of a new in vitro model of the stroke penumbra.
J Neurosci. 2008 Jun 25;28(26):6537-8. doi: 10.1523/JNEUROSCI.1841-08.2008.
10
Cerebral metabolic adaptation and ketone metabolism after brain injury.
J Cereb Blood Flow Metab. 2008 Jan;28(1):1-16. doi: 10.1038/sj.jcbfm.9600543. Epub 2007 Aug 8.
Zotero 插件