Dietze Eric C, Sistrunk Christopher, Miranda-Carboni Gustavo, O'Regan Ruth, Seewaldt Victoria L
1] Duke University, Durham, North Carolina 27710, USA. [2].
1] University of Tennessee Health Science Center, Memphis, Tennessee 90095, USA. [2].
Nat Rev Cancer. 2015 Apr;15(4):248-54. doi: 10.1038/nrc3896. Epub 2015 Feb 12.
Triple-negative breast cancer (TNBC) is an aggressive breast cancer subtype that disproportionately affects BRCA1 mutation carriers and young women of African origin. There is evidence that African-American women with TNBC have worse clinical outcomes than women of European descent. However, it is unclear whether survival differences persist after adjusting for disparities in access to health-care treatment, co-morbid disease and income. It remains controversial whether TNBC in African-American women is a molecularly distinct disease or whether African-American women have a higher incidence of aggressive biology driven by disparities: there is evidence in support of both. Understanding the relative contributions of biology and disparities is essential for improving the poor survival rate of African-American women with TNBC.
三阴性乳腺癌（TNBC）是一种侵袭性乳腺癌亚型，对携带BRCA1突变的人群以及非洲裔年轻女性影响尤为严重。有证据表明，患有三阴性乳腺癌的非裔美国女性的临床结局比欧洲裔女性更差。然而，在调整了医疗保健治疗机会、合并疾病和收入方面的差异后，生存差异是否仍然存在尚不清楚。非裔美国女性的三阴性乳腺癌是否是一种分子上不同的疾病，或者非裔美国女性是否由于差异而具有更高的侵袭性生物学发病率，这仍然存在争议：两种观点都有证据支持。了解生物学因素和差异因素的相对作用对于提高患有三阴性乳腺癌的非裔美国女性的低生存率至关重要。
