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对145例弓形虫血清转化病例采用IgA免疫吸附凝集试验诊断先天性弓形虫病的评估。

Assessment of the IgA immunosorbent agglutination assay for the diagnosis of congenital toxoplasmosis on a series of 145 toxoplasmic seroconversions.

作者信息

Murat J B, Souvignet A, Fricker-Hidalgo H, Brenier-Pinchart M P, Bost-Bru C, Pelloux H

机构信息

Laboratory of Parasitology and Mycology, Grenoble University Hospital, Grenoble, France UMR 5163 CNRS, Université Grenoble Alpes, Saint Martin d'Hères, France

Laboratory of Parasitology and Mycology, Grenoble University Hospital, Grenoble, France.

出版信息

Clin Vaccine Immunol. 2015 Apr;22(4):456-8. doi: 10.1128/CVI.00666-14. Epub 2015 Feb 11.

DOI:10.1128/CVI.00666-14
PMID:25673306
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4375347/
Abstract

A retrospective analysis of 145 medical records from our teaching hospital laboratory showed an overall specificity of greater than 97% for the IgA immunosorbent agglutination assay (ISAGA A) performed on the sera of babies to diagnose congenital toxoplasmosis (CT). These actualized data emphasize the ability of this test to confirm a diagnosis of congenital toxoplasmosis.

摘要

对我们教学医院实验室的145份病历进行的回顾性分析显示，对婴儿血清进行的用于诊断先天性弓形虫病（CT）的IgA免疫吸附凝集试验（ISAGA A）的总体特异性大于97%。这些实际数据强调了该检测方法在确诊先天性弓形虫病方面的能力。

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Assessment of the IgA immunosorbent agglutination assay for the diagnosis of congenital toxoplasmosis on a series of 145 toxoplasmic seroconversions.对145例弓形虫血清转化病例采用IgA免疫吸附凝集试验诊断先天性弓形虫病的评估。
Clin Vaccine Immunol. 2015 Apr;22(4):456-8. doi: 10.1128/CVI.00666-14. Epub 2015 Feb 11.
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本文引用的文献

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Epidemiology of and diagnostic strategies for toxoplasmosis.弓形虫病的流行病学和诊断策略。
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Severe congenital toxoplasmosis in the United States: clinical and serologic findings in untreated infants.美国严重先天性弓形虫病：未经治疗婴儿的临床和血清学发现。
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Screening for congenital toxoplasmosis: accuracy of immunoglobulin M and immunoglobulin A tests after birth.先天性弓形虫病筛查：出生后免疫球蛋白M和免疫球蛋白A检测的准确性
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Toxoplasma gondii infection in pregnancy: opportunities and pitfalls of serological diagnosis.妊娠期弓形虫感染：血清学诊断的机遇与陷阱
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Comparison of two DNA targets for the diagnosis of Toxoplasmosis by real-time PCR using fluorescence resonance energy transfer hybridization probes.使用荧光共振能量转移杂交探针通过实时PCR诊断弓形虫病时两种DNA靶标的比较
BMC Infect Dis. 2003 May 2;3:7. doi: 10.1186/1471-2334-3-7.
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J Clin Microbiol. 2001 Jun;39(6):2267-71. doi: 10.1128/JCM.39.6.2267-2271.2001.
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Neonatal screening for congenital toxoplasmosis in a cohort of 165 women infected during pregnancy and influence of in utero treatment on the results of neonatal tests.对165名孕期感染的女性队列进行先天性弓形虫病的新生儿筛查以及宫内治疗对新生儿检测结果的影响。
Eur J Obstet Gynecol Reprod Biol. 2001 Jan;94(1):37-45. doi: 10.1016/s0301-2115(00)00300-6.
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Value of prenatal diagnosis and early postnatal diagnosis of congenital toxoplasmosis: retrospective study of 110 cases.先天性弓形虫病产前诊断及产后早期诊断的价值：110例回顾性研究
J Clin Microbiol. 1999 Sep;37(9):2893-8. doi: 10.1128/JCM.37.9.2893-2898.1999.
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Lack of value of specific IgA detection in the postnatal diagnosis of congenital toxoplasmosis.特异性IgA检测在先天性弓形虫病产后诊断中的价值缺失。
J Clin Lab Anal. 1999;13(1):27-30. doi: 10.1002/(sici)1098-2825(1999)13:1<27::aid-jcla5>3.0.co;2-y.