Nakagoe T, Hirota M, Hiratani K, Fukushima K, Shimoyama T, Miura T, Tomita M, Hara K, Ifuku M
Nihon Shokakibyo Gakkai Zasshi. 1989 Jan;86(1):19-25.
Sialylated Lewis(x) and sialylated Lewis(a) antigens, which are structural isomer each other, were serologically tested to determine the clinicopathological differences and correlation between two antigens, and were also compared with those of serum CEA in 141 patients with gastric cancer. Percent positives in sialylated Lewis(a), CEA and sialylated Lewis(x) showed 26.9%, 21.8% and 17.0% respectively. Percent positive of sialylated Lewis(x) correlated with degree of liver metastasis and peritoneal dissemination. Therefore, it is emphasized that the role of sialylated Lewis(x) is characteristics of detecting a presence of liver metastasis and/or peritoneal dissemination. On the other hand, sialylated Lewis(a) showed high percent positive in cases which had lymph nodes metastasis and mucinous or papillary adenocarcinomas. These two carbohydrate antigens indicated no correlation (r = 0.062) in the spectrum of sera. It is suggested that combination assay of sialylated Lewis(x) and sialylated Lewis(a) is useful in detecting many gastric cancer patients including CEA-negative one.
唾液酸化Lewis(x)和唾液酸化Lewis(a)抗原互为结构异构体，对其进行血清学检测以确定两种抗原之间的临床病理差异及相关性，并与141例胃癌患者的血清癌胚抗原（CEA）进行比较。唾液酸化Lewis(a)、CEA和唾液酸化Lewis(x)的阳性率分别为26.9%、21.8%和17.0%。唾液酸化Lewis(x)的阳性率与肝转移和腹膜播散程度相关。因此，强调唾液酸化Lewis(x)的作用在于检测肝转移和/或腹膜播散的存在。另一方面，唾液酸化Lewis(a)在有淋巴结转移以及黏液性或乳头状腺癌的病例中显示出较高的阳性率。这两种碳水化合物抗原在血清谱中无相关性（r = 0.062）。提示唾液酸化Lewis(x)和唾液酸化Lewis(a)联合检测有助于发现包括CEA阴性患者在内的许多胃癌患者。
