Ikeda Y, Mori M, Kamakura T, Saku M, Sugimachi K
Second Department of Surgery, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Eur J Surg Oncol. 1995 Apr;21(2):168-75. doi: 10.1016/s0748-7983(95)90369-0.
Immunohistochemical expression of sialyl Tn antigen (TKH2 and B72.3), sialyl Lewis(a) antigen (CA19-9) and CEA was examined in 52 cases with Stage IV gastric cancer, the objective being to examine whether or not these tumour-associated antigens show different expression between peritoneal dissemination and liver metastasis. Stromal type for TKH2, B72.3, CA19-9 and CEA were seen in 14 (50%), 13 (46%), 18 (64%) and nine (32%) cases with peritoneal dissemination, respectively, and in four (17%), three (13%), four (17%) and four (17%) cases with liver metastasis, respectively. The stromal type correlated to peritoneal dissemination in TKH2 (P < 0.05) B72.3 (P < 0.05) and CA19-9 (P < 0.05). In other clinicopathological factors, the stromal type for TKH2, B72.3 and CA19-9 correlated to the undifferentiated type. However, even in the undifferentiated type group, the stromal type correlated to peritoneal dissemination in TKH2 (P < 0.05), B72.3 (P < 0.05) and CA19-9 (P < 0.05). Based on these results, the spread of sialyl-rich tumour-associated antigens into the surrounding stroma in the undifferentiated type of gastric cancer may be associated with peritoneal dissemination.
对52例IV期胃癌患者检测了唾液酸化Tn抗原（TKH2和B72.3）、唾液酸化Lewis(a)抗原（CA19-9）和癌胚抗原（CEA）的免疫组化表达，目的是研究这些肿瘤相关抗原在腹膜播散和肝转移之间是否表现出不同的表达。TKH2、B72.3、CA19-9和CEA的间质型分别见于14例（50%）、13例（46%）、18例（64%）和9例（32%）腹膜播散患者，以及4例（17%）、3例（13%）、4例（17%）和4例（17%）肝转移患者。TKH2（P<0.05）、B72.3（P<0.05）和CA19-9（P<0.05）的间质型与腹膜播散相关。在其他临床病理因素中，TKH2、B72.3和CA19-9的间质型与未分化型相关。然而，即使在未分化型组中，TKH2（P<0.05）、B72.3（P<0.05）和CA19-9（P<0.05）的间质型也与腹膜播散相关。基于这些结果，未分化型胃癌中富含唾液酸的肿瘤相关抗原向周围间质的扩散可能与腹膜播散有关。
