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脊椎动物运动神经元中的骨形态发生蛋白信号传导与神经肌肉通讯

Bone morphogenetic protein signaling in vertebrate motor neurons and neuromuscular communication.

作者信息

Osses Nelson, Henríquez Juan P

机构信息

BMP Research Group, Institute of Chemistry, Faculty of Sciences, Pontificia Universidad Católica de Valparaíso Valparaíso, Chile.

Laboratory of Developmental Neurobiology, Department of Cell Biology, Faculty of Biological Sciences, Millennium Nucleus of Regenerative Biology, Center for Advanced Microscopy (CMA Bio-Bio), Universidad de Concepción Concepción, Chile.

出版信息

Front Cell Neurosci. 2015 Jan 27;8:453. doi: 10.3389/fncel.2014.00453. eCollection 2014.

DOI:10.3389/fncel.2014.00453
PMID:25674047
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4307192/
Abstract

An accurate communication between motor neurons and skeletal muscle fibers is required for the proper assembly, growth and maintenance of neuromuscular junctions (NMJs). Several signaling and extracellular matrix molecules play stimulatory and inhibitory roles on the assembly of functional synapses. Studies in Drosophila have revealed crucial functions for early morphogens, such as members of the Wnt and Bone Morphogenetic Proteins (BMP) signaling pathways, during the assembly and maturation of the NMJ. Here, we bring together recent findings that led us to propose that BMPs also work in vertebrate organisms as diffusible cues to communicate motor neurons and skeletal muscles.

摘要

运动神经元与骨骼肌纤维之间的准确通讯对于神经肌肉接头（NMJ）的正确组装、生长和维持至关重要。几种信号和细胞外基质分子在功能性突触的组装中发挥刺激和抑制作用。果蝇研究揭示了早期形态发生素，如Wnt和骨形态发生蛋白（BMP）信号通路成员，在NMJ组装和成熟过程中的关键作用。在这里，我们汇总了最近的研究结果，这些结果使我们提出，BMPs在脊椎动物中也作为可扩散信号发挥作用，用于运动神经元与骨骼肌之间的通讯。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd63/4307192/ed5496923878/fncel-08-00453-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd63/4307192/c96a8eed1787/fncel-08-00453-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd63/4307192/ed5496923878/fncel-08-00453-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd63/4307192/c96a8eed1787/fncel-08-00453-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd63/4307192/ed5496923878/fncel-08-00453-g0002.jpg

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