Moss D E, Manderscheid P Z, Montgomery S P, Norman A B, Sanberg P R
Laboratory of Psychobiochemistry, University of Texas El Paso 79968.
Life Sci. 1989;44(21):1521-5. doi: 10.1016/0024-3205(89)90444-x.
Animal studies suggest nicotine and cannabinoids may significantly enhance the therapeutic value of neuroleptics in motor disorders. This was recently demonstrated in humans by the finding that chewing nicotine gum produced striking relief from tics and other symptoms of Tourette syndrome not controlled by neuroleptic treatment alone. It appears that the use of nicotine or cannabinoids may greatly improve the clinical response to neuroleptics in motor disorders.
动物研究表明，尼古丁和大麻素可能会显著提高抗精神病药物在运动障碍治疗中的价值。最近在人类身上也证实了这一点，研究发现咀嚼尼古丁口香糖能显著缓解抽动秽语综合征的抽搐及其他症状，而这些症状仅靠抗精神病药物治疗无法得到控制。看来，使用尼古丁或大麻素可能会大大改善运动障碍患者对抗精神病药物的临床反应。
