a Division of Immunopathology of the Nervous System , Department of Neuropathology , Institute of Pathology and Neuropathology, University of Tuebingen , Tuebingen , Germany.
Crit Rev Food Sci Nutr. 2017 Feb 11;57(3):613-631. doi: 10.1080/10408398.2014.906382.
Hesperidin, a member of the flavanone group of flavonoids, can be isolated in large amounts from the rinds of some citrus species. Considering the wide range of pharmacological activities and widespread application of hesperidin, this paper reviews preclinical and clinical trials of hesperidin and its related compounds, including their occurrence, pharmacokinetics, and some marketed products available. Preclinical studies and clinical trials demonstrated therapeutical effects of hesperidin and its aglycone hesperetin in various diseases, such as neurological disorders, psychiatric disorders, and cardiovascular diseases and others, due to its anti-inflammatory, antioxidant, lipid-lowering, and insulin-sensitizing properties.
橙皮苷是类黄酮中黄烷酮的一个成员，可大量从某些柑橘属果皮中分离出来。鉴于橙皮苷具有广泛的药理活性和广泛的应用，本文综述了橙皮苷及其相关化合物的临床前和临床试验，包括它们的发生、药代动力学和一些市售产品。临床前研究和临床试验表明，橙皮苷及其苷元橙皮素具有治疗作用，可用于治疗各种疾病，如神经紊乱、精神障碍、心血管疾病等，这是由于其具有抗炎、抗氧化、降血脂和胰岛素增敏作用。
