Chen Thomas, Powell Cynthia C
Department of Small Animal Clinical Sciences, C247 Veterinary Medical Center, University of Tennessee, Knoxville, TN, 37996, USA.
Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, 300 W. Drake Rd., Fort Collins, CO, 80523, USA.
Vet Ophthalmol. 2015 Nov;18(6):497-501. doi: 10.1111/vop.12255. Epub 2015 Feb 10.
To determine the effect of once daily topical 0.3% naltrexone (NTX) on tear production, tear film breakup time (TFBUT), and corneal sensitivity in dogs with uncontrolled keratoconjunctivitis sicca (KCS).
Sixteen dogs with uncontrolled KCS.
A randomized placebo-controlled trial was performed in 16 dogs with topical 0.3% NTX once daily or topical saline solution drops once daily. A baseline was obtained at week 0 for tear production (Schirmer tear test 1 and 2-STT1, STT2), TFBUT, and corneal sensitivity. STT1, STT2, and TFBUT were then subsequently measured at weeks 1, 2, and 4 while on NTX or saline drops. Corneal sensitivity measures were repeated at week 4. The drops were subsequently discontinued and all parameters rechecked at week 5.
There was no statistically significant difference in tear parameters or corneal sensitivity between the NTX-treated and the saline-treated groups.
Topical 0.3% NTX given as a once daily dose over 4 weeks did not alter tear production, tear film stability, or corneal sensitivity in dogs with uncontrolled KCS.
确定每日一次局部应用0.3%纳曲酮（NTX）对患有未控制的干眼症（KCS）的犬泪液分泌、泪膜破裂时间（TFBUT）和角膜敏感性的影响。
16只患有未控制的KCS的犬。
对16只犬进行了一项随机安慰剂对照试验，一组每日一次局部应用0.3%NTX，另一组每日一次局部应用盐溶液滴剂。在第0周获得泪液分泌（Schirmer泪液试验1和2 - STT1、STT2）、TFBUT和角膜敏感性的基线数据。然后在第1、2和4周测量NTX或盐溶液滴剂治疗期间的STT1、STT2和TFBUT。在第4周重复角膜敏感性测量。随后停用滴剂，并在第5周重新检查所有参数。
NTX治疗组和盐溶液治疗组之间的泪液参数或角膜敏感性无统计学显著差异。
在4周内每日一次给予局部0.3%NTX，并未改变患有未控制的KCS的犬的泪液分泌、泪膜稳定性或角膜敏感性。
