茶碱过量导致的乳酸性酸中毒。

Lactic acidosis in theophylline overdose.

作者信息

Leventhal L J, Kochar G, Feldman N H, Podolsky S M, Stanek M S

机构信息

Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia 19104-4283.

出版信息

Am J Emerg Med. 1989 Jul;7(4):417-8. doi: 10.1016/0735-6757(89)90052-1.

DOI:10.1016/0735-6757(89)90052-1

PMID:2567599

Abstract

An 18-year-old man with theophylline overdose developed an increased anion gap metabolic acidosis. Serum lactate levels were markedly elevated. A direct correlation was found between the increasing theophylline level, clinical hyperadrenergic state, and the worsening acidosis. Early hemoperfusion reversed the acidosis, the elevated serum theophylline level, and the hyperadrenergic state. This case substantiates the role of lactate accumulation in the metabolic acidosis associated with isolated theophylline toxicity.

摘要

一名18岁的氨茶碱过量男性患者出现了阴离子间隙增加的代谢性酸中毒。血清乳酸水平显著升高。发现氨茶碱水平升高、临床高肾上腺素能状态与酸中毒加重之间存在直接关联。早期血液灌流逆转了酸中毒、血清氨茶碱水平升高以及高肾上腺素能状态。该病例证实了乳酸堆积在单纯氨茶碱中毒相关代谢性酸中毒中的作用。