利用傅里叶域光学相干断层扫描和微视野计评估缺血性糖尿病性黄斑病变
Evaluation of ischemic diabetic maculopathy with Fourier-domain optical coherence tomography and microperimetry.
作者信息
Cennamo Gilda, Vecchio Elisabetta Chiariello, Finelli Marialuisa, Velotti Nunzio, de Crecchio Giuseppe
机构信息
Eye Clinic, Department of Neurosciences, Reproductive Sciences, and Dentistry, University Naples Federico II, Naples, Italy.
Eye Clinic, Department of Neurosciences, Reproductive Sciences, and Dentistry, University Naples Federico II, Naples, Italy.
出版信息
Can J Ophthalmol. 2015 Feb;50(1):44-8. doi: 10.1016/j.jcjo.2014.08.005.
OBJECTIVE
To evaluate the efficacy of high-speed Fourier-domain optical coherence tomography (FD-OCT) and fundus microperimetry (MP-1) in identifying the anatomic and functional features of ischemic diabetic maculopathy.
DESIGN
Prospective noninterventional study.
PARTICIPANTS
Forty-two consecutive eyes (23 patients) with ischemic diabetic maculopathy and 40 normal eyes (25 control subjects) were included in this study.
METHODS
Best corrected visual acuity, ganglion cell complex (GCC) thickness measured with FD-OCT, and central light sensitivity recorded with MP-1 were evaluated.
RESULTS
GCC thickness and light sensitivity were significantly reduced in all affected eyes versus control eyes. logMAR BVCA was significantly correlated with mean macular sensitivity (R=0.783, R(2)=0.611).
CONCLUSIONS
GCC thickness and microperimetry integrated with fluorescein angiography could be a marker of retinal vascular abnormalities that is useful for the diagnosis of ischemic diabetic maculopathy.
目的
评估高速傅里叶域光学相干断层扫描（FD-OCT）和眼底微视野计（MP-1）在识别缺血性糖尿病性黄斑病变的解剖和功能特征方面的疗效。
设计
前瞻性非干预性研究。
参与者
本研究纳入了42只连续的缺血性糖尿病性黄斑病变眼（23例患者）和40只正常眼（25名对照受试者）。
方法
评估最佳矫正视力、用FD-OCT测量的神经节细胞复合体（GCC）厚度以及用MP-1记录的中心光敏感度。
结果
与对照眼相比，所有患眼中GCC厚度和光敏感度均显著降低。logMAR BCVA与平均黄斑敏感度显著相关（R = 0.783，R² = 0.611）。
结论
GCC厚度和微视野计检查结合荧光素血管造影可能是视网膜血管异常的一个标志物，有助于缺血性糖尿病性黄斑病变的诊断。
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