Rao Krishna, Young Vincent B
Division of Infectious Diseases, Department of Internal Medicine, University of Michigan School of Medicine, 1500 East Medical Center Drive, Ann Arbor, MI 48109, USA; Division of Infectious Diseases, Department of Internal Medicine, Veterans Affairs Ann Arbor Healthcare System, 2215 Fuller Road, Ann Arbor, MI 48105, USA.
Division of Infectious Diseases, Department of Internal Medicine, University of Michigan School of Medicine, 1500 East Medical Center Drive, Ann Arbor, MI 48109, USA; Department of Microbiology and Immunology, University of Michigan School of Medicine, 1150 West Medical Center Drive, Ann Arbor, MI 48109, USA.
Infect Dis Clin North Am. 2015 Mar;29(1):109-22. doi: 10.1016/j.idc.2014.11.009.
This article discusses the use of fecal microbiota transplantation (FMT) for the treatment of recurrent Clostridium difficile infection (CDI). The disruption of the normal gut microbiota is central to the pathogenesis of CDI, and disruption persists in recurrent disease. The use of FMT for recurrent CDI is characterized by a high response rate and short term safety is excellent, although the long-term effects of FMT are as yet unknown.
本文讨论了粪便微生物群移植（FMT）用于治疗复发性艰难梭菌感染（CDI）的情况。正常肠道微生物群的破坏是CDI发病机制的核心，且这种破坏在复发性疾病中持续存在。FMT用于复发性CDI的特点是缓解率高且短期安全性良好，不过FMT的长期影响尚不清楚。
