Abdel-Rahman Omar
Clinical Oncology Department, Faculty of Medicine, Ain shams University, Cairo, Egypt,
Tumour Biol. 2015 Mar;36(3):1367-74. doi: 10.1007/s13277-015-3216-6. Epub 2015 Feb 14.
Gastric cancer is an important cause for mortality and morbidity worldwide; it lies in the fourt rank as a cause of cancer-related death in males and in the fifth rank of cancer-related death in women. The prognosis of advanced/metastatic gastric cancer cases looks poor with the majority of available therapeutics. Thus, novel therapeutic strategies in this setting have been considered a priority for leading cooperative oncology groups. Hedgehog(Hh) pathway aberrations have sparked particular interest as prognostic markers with data from multiple studies showing consistent evidence of a poor prognostic value of Gli over expression in gastric cancer while on the other hand the prognostic significance of Hh protein over expression (particularly SHH) was not consistent among different studies. This review article revises the prognostic and potential therapeutic opportunities in the targeting of hedgehog pathway in gastric cancer.
胃癌是全球范围内导致死亡和发病的重要原因；在男性中，它是癌症相关死亡的第四大原因，在女性中则是第五大原因。大多数现有治疗方法对晚期/转移性胃癌病例的预后看起来不佳。因此，在这种情况下，新型治疗策略一直被领先的肿瘤协作组视为优先事项。刺猬（Hh）信号通路异常作为预后标志物引发了特别关注，多项研究的数据一致表明，Gli在胃癌中过度表达具有不良预后价值，而另一方面，不同研究中Hh蛋白过度表达（特别是SHH）的预后意义并不一致。这篇综述文章探讨了针对胃癌中刺猬信号通路的预后及潜在治疗机会。
