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构建和验证用于胃腺癌及免疫浸润的焦亡相关基因预后特征：预测总生存的潜在生物标志物

Constructing and Validating a Pyroptosis-Related Genes Prognostic Signature for Stomach Adenocarcinoma and Immune Infiltration: Potential Biomarkers for Predicting the Overall Survival.

作者信息

Xu Jingmin, Chen Ke, Wei Zhou, Wu Zixuan, Huang Xuyan, Cai Minjie, Yuan Kai, Huang Peidong, Zhang Jing, Wang Shuai

机构信息

Yantai Hospital of Traditional Chinese Medicine, Shandong Province, China.

Department of Clinical Laboratory, The Sixth Affiliated Hospital of Sun Yat-Sen University, Guangzhou, 510655 Guangdong, China.

出版信息

J Oncol. 2022 Sep 26;2022:3102743. doi: 10.1155/2022/3102743. eCollection 2022.

DOI:10.1155/2022/3102743
PMID:36199800
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9529402/
Abstract

BACKGROUND

Stomach adenocarcinoma (STAD) is a kind of cancer that begins in the stomach cells and has a poor overall survival rate. Following resection surgery, chemotherapy has been suggested as a curative method for stomach cancer. However, it is ineffective. Pyroptosis, a kind of inflammatory programmed cell death, has been shown to play a significant role in the development and progression of STAD. However, whether pyroptosis-related genes (PRGs) can be utilized to predict the diagnosis and prognosis of gastric cancer remains unknown.

METHOD

The research measured at predictive PRGs in STAD samples from TCGA and GEO. Lasso regression was used to build the prediction model. Coexpression analysis revealed that gene expression was linked to pyroptosis. PRGs were found to be overexpressed in high-risk individuals, implying that they could be used in a model to predict STAD prognosis.

RESULT

Immunological and tumor-related pathways were discovered using GSEA. In STAD patients, the genes , , , and may be connected to the cancer process. The levels of expression also differed between the two risk groups.

CONCLUSION

The purpose of this study is to identify and verify STAD-associated PRGs that can effectively guide prognosis and the immunological milieu in STAD patients as well as offer evidence for the development of pyroptosis-related molecularly targeted therapeutics. Therefore, PRGs and the link between immunological and PRGs in STAD may be therapeutic targets.

摘要

背景

胃腺癌（STAD）是一种起源于胃细胞的癌症，总体生存率较低。切除手术后，化疗被认为是胃癌的一种治疗方法。然而，它并不有效。细胞焦亡是一种炎症性程序性细胞死亡，已被证明在胃腺癌的发生和发展中起重要作用。然而，细胞焦亡相关基因（PRGs）是否可用于预测胃癌的诊断和预后仍不清楚。

方法

该研究检测了来自TCGA和GEO的STAD样本中的预测性PRGs。采用套索回归构建预测模型。共表达分析表明基因表达与细胞焦亡有关。发现PRGs在高危个体中过表达，这意味着它们可用于预测STAD预后的模型中。

结果

使用GSEA发现了免疫和肿瘤相关途径。在STAD患者中，基因 、 、 和 可能与癌症进程有关。两个风险组之间的表达水平也有所不同。

结论

本研究的目的是识别和验证与STAD相关的PRGs，这些基因可以有效地指导STAD患者的预后和免疫环境，并为细胞焦亡相关分子靶向治疗的开发提供证据。因此，PRGs以及STAD中免疫与PRGs之间的联系可能是治疗靶点。

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