哮喘中的碳氧血红蛋白和高铁血红蛋白。
Carboxyhemoglobin and methemoglobin in asthma.
作者信息
Naples Robert, Laskowski Dan, McCarthy Kevin, Mattox Emmea, Comhair Suzy A A, Erzurum Serpil C
机构信息
Department of Pathobiology, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Ave/NC22, Cleveland, OH, 44195, USA.
出版信息
Lung. 2015 Apr;193(2):183-7. doi: 10.1007/s00408-015-9686-x. Epub 2015 Feb 14.
Nitric oxide (NO) and carbon monoxide (CO) are synthesized at high levels in asthmatic airways. NO can oxidize hemoglobin (Hb) to methemoglobin (MetHb). CO binds to heme to produce carboxyhemoglobin (COHb). We hypothesized that MetHb and COHb may be increased in asthma. COHb, MetHb, and Hb were measured in venous blood of healthy controls (n = 32) and asthmatics (n = 31). Arterial COHb and oxyhemoglobin were measured by pulse CO-oximeter. Hb, oxyhemoglobin, and deoxyhemoglobin were similar among groups, but arterial COHb was higher in asthmatics than controls (p = 0.04). Venous COHb was similar among groups, and thus, arteriovenous COHb (a-v COHb) concentration difference was greater in asthma compared with controls. Venous MetHb was lower in asthma compared to controls (p = 0.01) and correlated to venous NO (p = 0.009). The greater a-v COHb in asthma suggests CO offloading to tissues, but lower than normal MetHb suggests countermeasures to avoid adverse effects of high NO on gas transfer.
一氧化氮（NO）和一氧化碳（CO）在哮喘气道中大量合成。NO可将血红蛋白（Hb）氧化为高铁血红蛋白（MetHb）。CO与血红素结合生成碳氧血红蛋白（COHb）。我们推测哮喘患者体内的MetHb和COHb可能会增加。对健康对照者（n = 32）和哮喘患者（n = 31）的静脉血进行了COHb、MetHb和Hb检测。通过脉搏碳氧血红蛋白仪测量动脉血中的COHb和氧合血红蛋白。各组之间的Hb、氧合血红蛋白和脱氧血红蛋白相似，但哮喘患者的动脉COHb高于对照组（p = 0.04）。各组之间的静脉COHb相似，因此，与对照组相比，哮喘患者的动静脉COHb（a-v COHb）浓度差更大。与对照组相比，哮喘患者的静脉MetHb较低（p = 0.01），且与静脉NO相关（p = 0.009）。哮喘患者较大的a-v COHb表明CO向组织卸载，但低于正常水平的MetHb表明采取了应对措施以避免高浓度NO对气体交换产生的不利影响。
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