Biedebach M C
Dept. of Anatomy & Physiology, California State University, Long Beach 90840-3701.
Acupunct Electrother Res. 1989;14(1):43-60. doi: 10.3727/036012989816358579.
Evidence is reviewed (8 studies involving 215 clinical patients with ischemic skin ulcers and 7 animal tissue or tissue culture studies) that electrical stimulation of fibroblast cells accelerates the intracellular biosynthesis necessary to form new granulation tissue in a healing wound, and that both a direct local tissue effect and a circulatory improvement occur. A model is presented in which transmembrane currents open voltage-controlled calcium channels in fibroblast cells, causing ATP resynthesis, activation of protein kinase mechanisms to synthesize new cellular protein, and the DNA replication necessary for mitotic cell division. Stimulation efficacy appears to be determined by a number of basic electrical parameters, and judicious waveform control is desirable.
（对8项涉及215例缺血性皮肤溃疡临床患者的研究以及7项动物组织或组织培养研究进行了综述）有证据表明，对成纤维细胞进行电刺激可加速愈合伤口中形成新肉芽组织所需的细胞内生物合成，并且会产生直接的局部组织效应和循环改善。本文提出了一个模型，其中跨膜电流打开成纤维细胞中的电压控制钙通道，导致ATP重新合成、激活蛋白质激酶机制以合成新的细胞蛋白质，以及有丝分裂细胞分裂所需的DNA复制。刺激效果似乎由一些基本电参数决定，因此需要明智地控制波形。
