Kaada B, Emru M
Rogaland Central Hospital, Armauer Hansens Vei, Stavanger, Norway.
Acupunct Electrother Res. 1988;13(4):165-76. doi: 10.3727/036012988816358589.
Low-frequency (2 Hz) transcutaneous electrical nerve stimulation (TNS) may produce widespread and prolonged increases in skin temperature in patients with peripheral vascular insufficiency due to improved microcirculation. The method has previously been used successfully to potentiate healing of chronic ulcers of various etiology. The present report describes a similar study, using TNS treatment in attempts to accelerate healing of chronic leprous ulcers that had resisted treatment for several months or years. All other treatment, local and systemic chemotherapy, and daily regime remained as far as possible unaltered. The study was limited to ulceration in the soft tissue of the foot or lower leg. Eleven TNS sessions, each of 30 min duration, were applied per week. In 19 patients (6 out- and 13 in-patients), in whom the TNS treatment was not interrupted, all ulcers healed completely within a mean of 5.2 weeks (range 3-12 weeks). The mean size of the ulcers was 5.2 cu.cm (range 0.2-48.3 cu.cm), and they had persisted for a mean of 15.8 months (range 2-60 months). The 'healing index', i.e. the mean reduction of the ulcer cavity per week, was 1.0 cu.cm/week. The study demonstrates a clear therapeutic effect for low-frequency TNS in patients with leprous ulcers. The mechanisms involved in the accelerated healing are assumed to be increased microcirculation due to sympatho-inhibition and release of endogenous corticosteroids.
低频（2赫兹）经皮电神经刺激（TNS）可能会使外周血管功能不全患者的皮肤温度广泛且持续升高，这是因为微循环得到了改善。该方法此前已成功用于促进各种病因引起的慢性溃疡的愈合。本报告描述了一项类似的研究，使用TNS治疗试图加速对抵抗治疗数月或数年的慢性麻风溃疡的愈合。所有其他治疗，包括局部和全身化疗以及日常治疗方案，尽可能保持不变。该研究仅限于足部或小腿软组织的溃疡。每周进行11次TNS治疗，每次持续30分钟。在19例患者（6例门诊患者和13例住院患者）中，TNS治疗未中断，所有溃疡在平均5.2周（范围3 - 12周）内完全愈合。溃疡的平均大小为5.2立方厘米（范围0.2 - 48.3立方厘米），它们平均持续了15.8个月（范围2 - 60个月）。“愈合指数”，即溃疡腔每周的平均缩小量，为1.0立方厘米/周。该研究表明低频TNS对麻风溃疡患者具有明显的治疗效果。加速愈合所涉及的机制被认为是由于交感神经抑制和内源性皮质类固醇的释放导致微循环增加。
