变铅青链霉菌TK24的全基因组序列
Complete genome sequence of Streptomyces lividans TK24.
作者信息
Rückert Christian, Albersmeier Andreas, Busche Tobias, Jaenicke Sebastian, Winkler Anika, Friðjónsson Ólafur H, Hreggviðsson Guðmundur Óli, Lambert Christophe, Badcock Daniel, Bernaerts Kristel, Anne Jozef, Economou Anastassios, Kalinowski Jörn
机构信息
Center for Biotechnology (CeBiTec), Universität Bielefeld, Bielefeld, Germany.
Matís, Vínlandsleið 12, 113 Reykjavík, Iceland.
出版信息
J Biotechnol. 2015 Apr 10;199:21-2. doi: 10.1016/j.jbiotec.2015.02.004. Epub 2015 Feb 11.
Streptomyces lividans TK24 is the standard host for the heterologous expression of a number of different proteins and antibiotic-synthesizing enzymes. As such, it is often used as an experimental microbial cell factory for the production of secreted heterologous proteins including human cytokines and industrial enzymes, and of several antibiotics. It accepts methylated DNA and is an ideal Streptomyces cloning system. Here, we report the complete genome sequence of S. lividans TK24 that includes a plasmid-less genome of 8.345Mbp (72.24% G+C content).
变铅青链霉菌TK24是许多不同蛋白质和抗生素合成酶异源表达的标准宿主。因此，它常被用作实验性微生物细胞工厂，用于生产包括人类细胞因子和工业酶在内的分泌型异源蛋白质以及多种抗生素。它能接受甲基化DNA，是一种理想的链霉菌克隆系统。在此，我们报告了变铅青链霉菌TK24的完整基因组序列，其无质粒基因组大小为8.345Mbp（G+C含量为72.24%）。
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