Uhrig Monika, Simons David, Ganten Maria-Katharina, Hassel Jessica C, Schlemmer Heinz-Peter
Department of Radiology, German Cancer Research Center (DKFZ) Heidelberg, Im Neuenheimer Feld 280; D-69120 Heidelberg, Germany.
Future Oncol. 2015;11(4):591-606. doi: 10.2217/fon.14.265.
Iodine quantification with dual energy computed tomography (DECT) enables quantitative assessment of contrast medium uptake. Our purpose was to investigate patterns of enhancement under BRAF inhibitor therapy by performing histogram analyses (HAs) of iodine maps.
MATERIALS & METHODS: A total of 11 stage IV melanoma patients (32 metastases) underwent DECT at baseline and at least one follow up. Iodine uptake and HAs including maximum HU value (MAX), mean HU value (MEAN) and standard deviation (STD) was calculated.
For BRAF-responders MEAN, MAX and STD decreased significantly (p < 0.05). Nonresponder showed increasing MAX and STD for six out of seven lesions, while MEAN and Iodine uptake decreased (four) and increased (three).
HA based on DECT enables a quantitative and functional criterion and contributes to accurate response assessment for promising targeted therapies.
采用双能计算机断层扫描（DECT）进行碘定量分析可实现对造影剂摄取的定量评估。我们的目的是通过对碘图进行直方图分析（HA）来研究BRAF抑制剂治疗下的强化模式。
共有11例IV期黑色素瘤患者（32处转移灶）在基线期及至少一次随访时接受了DECT检查。计算碘摄取量及包括最大HU值（MAX）、平均HU值（MEAN）和标准差（STD）在内的直方图分析结果。
对于BRAF反应者，MEAN、MAX和STD显著降低（p < 0.05）。无反应者的7处病灶中有6处的MAX和STD升高，而MEAN和碘摄取量降低（4处）和升高（3处）。
基于DECT的直方图分析可提供定量和功能标准，有助于对有前景的靶向治疗进行准确的反应评估。
