Mancini F R, Paul D, Gauvreau J, Volatier J L, Vin K, Hulin M
a Department of Veterinary Public Health and Food Safety , Istituto Superiore di Sanità , Rome , Italy.
Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2015;32(3):293-306. doi: 10.1080/19440049.2015.1007535. Epub 2015 Feb 16.
This study aimed to estimate the exposure to seven additives (benzoates, parabens, nitrites, nitrates, BHA, BHT and aspartame) in children aged less than 3 years old in France. A conservative approach, combining individual consumption data with maximum permitted levels, was carried out for all the additives. More refined estimates using occurrence data obtained from products' labels (collected by the French Observatory of Food Quality) were conducted for those additives that exceeded the acceptable daily intake (ADI). Information on additives' occurrence was obtained from the food labels. When the ADI was still exceeded, the exposure estimate was further refined using measured concentration data, if available. When using the maximum permitted level (MPL), the ADI was exceeded for benzoates (1.94 mg kg(-1) bw day(-1)), nitrites (0.09 mg kg(-1) bw day(-1)) and BHA (0.39 mg kg(-1) bw day(-1)) in 25%, 54% and 20% of the entire study population respectively. The main food contributors identified with this approach were current foods as these additives are not authorised in specific infant food: vegetable soups and broths for both benzoates and BHA, delicatessen and meat for nitrites. The exposure estimate was significantly reduced when using occurrence data, but in the upper-bound scenario the ADI was still exceeded significantly by the age group 13-36 months for benzoates (2%) and BHA (1%), and by the age group 7-12 months (16%) and 13-36 months (58%) for nitrites. Measured concentration data were available exclusively for nitrites and the results obtained using these data showed that the nitrites' intake was below the ADI for all the population considered in this study. These results suggest that refinement of exposure, based on the assessment of food levels, is needed to estimate the exposure of children to BHA and benzoates for which the risk of exceeding the ADI cannot be excluded when using occurrence data.
本研究旨在估算法国3岁以下儿童对七种添加剂(苯甲酸盐、对羟基苯甲酸酯、亚硝酸盐、硝酸盐、丁基羟基茴香醚、二丁基羟基甲苯和阿斯巴甜)的暴露量。针对所有添加剂,采用了一种将个体消费数据与最大允许水平相结合的保守方法。对于那些超过每日可接受摄入量(ADI)的添加剂,使用从产品标签(由法国食品质量观察站收集)获得的出现数据进行了更精确的估算。添加剂出现情况的信息来自食品标签。当ADI仍被超过时,如果有可用的测量浓度数据,则使用这些数据进一步细化暴露量估算。使用最大允许水平(MPL)时,苯甲酸盐(1.94毫克/千克体重/天)、亚硝酸盐(0.09毫克/千克体重/天)和丁基羟基茴香醚(0.39毫克/千克体重/天)分别在整个研究人群的25%、54%和20%中超过了ADI。用这种方法确定的主要食物来源是日常食品,因为这些添加剂在特定婴儿食品中未获批准:苯甲酸盐和丁基羟基茴香醚的主要来源是蔬菜汤和肉汤,亚硝酸盐的主要来源是熟食和肉类。使用出现数据时,暴露量估算显著降低,但在上限情况下,13 - 36个月龄组的苯甲酸盐(2%)和丁基羟基茴香醚(1%),以及7 - 12个月龄组(16%)和13 - 36个月龄组(58%)的亚硝酸盐仍显著超过ADI。仅亚硝酸盐有测量浓度数据,使用这些数据获得的结果表明,本研究中考虑的所有人群的亚硝酸盐摄入量均低于ADI。这些结果表明,需要基于食品水平评估来细化暴露量估算,以估计儿童对丁基羟基茴香醚和苯甲酸盐的暴露量,因为使用出现数据时不能排除超过ADI的风险。