Lee Li-Wan, Hsiao Sheng-Huang, Hung Wei-Chiang, Lin Yun-Ho, Chen Po-Yu, Chiang Chun-Pin
Department of Dentistry, Taipei City Hospital, Renai Branch, Taipei, Taiwan.
Department of Neurosurgery, Taipei City Hospital, Renai Branch, Taipei, Taiwan; Institute of Traditional Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan.
J Endod. 2015 May;41(5):628-36. doi: 10.1016/j.joen.2015.01.007. Epub 2015 Feb 14.
Mineral trioxide aggregate (MTA) is a biocompatible material for direct pulp capping. This study was designed to compare the clinical outcomes of pulp-exposed teeth treated with either poly(ε-caprolactone) fiber mesh (PCL-FM) as a barrier for MTA (so-called PCL-FM/MTA) or MTA direct pulp capping.
Sixty human vital teeth were evenly divided into 4 groups (n = 15 in each group). Teeth in groups 1 and 3 had pulp exposure <1 mm in diameter, whereas teeth in groups 2 and 4 had pulp exposure of 1-1.5 mm in diameter. Teeth in groups 1 and 2 were treated with PCL-FM/MTA direct pulp capping, and those in groups 3 and 4 were treated with MTA direct pulp capping.
Teeth treated with PCL-FM/MTA direct pulp capping needed a significantly shorter mean duration for dentin bridge formation than teeth treated with MTA direct pulp capping. Moreover, teeth with pulp exposure <1.0 mm in diameter needed a significantly shorter mean duration for dentin bridge formation than teeth with pulp exposure of 1-1.5 mm in diameter after either PCL-FM/MTA or MTA direct pulp capping treatment. In addition, teeth treated with PCL-FM/MTA direct pulp capping formed an approximately 3-fold thicker dentin bridge than teeth treated with MTA direct pulp capping 8 weeks or 3 months later. Furthermore, none of the teeth treated with PCL-FM/MTA direct pulp capping showed tooth discoloration after treatment for 3 months.
PCL-FM/MTA is a better combination material than MTA alone for direct pulp capping of human permanent teeth.
矿物三氧化物凝聚体（MTA）是一种用于直接盖髓的生物相容性材料。本研究旨在比较用聚（ε-己内酯）纤维网（PCL-FM）作为MTA的屏障（即所谓的PCL-FM/MTA）或MTA直接盖髓治疗露髓牙的临床效果。
60颗人类活髓牙平均分为4组（每组n = 15）。第1组和第3组的牙齿露髓直径<1 mm，而第2组和第4组的牙齿露髓直径为1 - 1.5 mm。第1组和第2组的牙齿采用PCL-FM/MTA直接盖髓治疗，第3组和第4组的牙齿采用MTA直接盖髓治疗。
与采用MTA直接盖髓治疗的牙齿相比，采用PCL-FM/MTA直接盖髓治疗的牙齿形成牙本质桥所需的平均时间明显更短。此外，在PCL-FM/MTA或MTA直接盖髓治疗后，露髓直径<1.0 mm的牙齿形成牙本质桥所需的平均时间明显短于露髓直径为1 - 1.5 mm的牙齿。此外，8周或3个月后，采用PCL-FM/MTA直接盖髓治疗的牙齿形成的牙本质桥比采用MTA直接盖髓治疗的牙齿厚约3倍。此外，采用PCL-FM/MTA直接盖髓治疗的牙齿在治疗3个月后均未出现牙齿变色。
对于人类恒牙直接盖髓，PCL-FM/MTA是比单独使用MTA更好的联合材料。
