用于无线遥测颅内压传感器涂层的热塑性橡胶的生物相容性评估。
Biocompatibility evaluation of a thermoplastic rubber for wireless telemetric intracranial pressure sensor coating.
作者信息
Yang Jun, Charif Andrea C, Puskas Judit E, Phillips Hannah, Shanahan Kaitlyn J, Garsed Jessica, Fleischman Aaron, Goldman Ken, Roy Shuvo, Luebbers Matthew T, Dombrowski Stephen M, Luciano Mark G
机构信息
Department of Neurosurgery, Section of Pediatric and Congenital Neurological Surgery, CSF Physiology Laboratory, Neurological Institute, S60, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA.
Department of Chemical and Biomolecular Engineering, the University of Akron, USA; Department of Polymer Science, the University of Akron, USA.
出版信息
J Mech Behav Biomed Mater. 2015 May;45:83-9. doi: 10.1016/j.jmbbm.2015.01.018. Epub 2015 Feb 3.
This study investigated the biocompatibility of the experimental thermoplastic rubber Arbomatrix(™) that will be used as the protective coating on a novel intracranial pressure (ICP) sensor silicon chip. Arbomatrix(™) was benchmarked against biocompatible commercial silicone rubber shunt tubing in the brain via a rat model with 60-day implant duration. A bare silicon chip was also implanted. The results showed similar cellular distribution in the brain-implant boundary and surrounding tissues. Quantitative analysis of neuron and glia density did not show significant difference between implants. Through histological and immunohistochemical evaluation we conclude that Arbomatrix(™) is well tolerated by the brain. Due to its exceptional barrier properties Arbomatrix(™) has already been shown to be an excellent protective coating for new ICP monitoring chip.
本研究调查了实验性热塑性橡胶Arbomatrix™的生物相容性，该橡胶将用作新型颅内压（ICP）传感器硅芯片的保护涂层。通过植入期为60天的大鼠模型，将Arbomatrix™与脑内具有生物相容性的商用硅橡胶分流管进行了对比。还植入了裸硅芯片。结果显示，在脑-植入物边界和周围组织中细胞分布相似。对神经元和神经胶质细胞密度的定量分析表明，各植入物之间没有显著差异。通过组织学和免疫组织化学评估，我们得出结论：大脑对Arbomatrix™耐受性良好。由于其卓越的阻隔性能，Arbomatrix™已被证明是新型ICP监测芯片的优秀保护涂层。
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