Rahman Obaidur
Department of Clinical Neuroscience, Karolinska Institutet, R5:U1, 171 76, Stockholm, Sweden; Bencar AB, Dag Hammarskjöldsväg 52B, 752 37, Uppsala, Sweden.
J Labelled Comp Radiopharm. 2015 Mar;58(3):86-98. doi: 10.1002/jlcr.3262. Epub 2015 Feb 16.
[(11) C]Carbon monoxide is an attractive precursor for labeling carbonyl position in a wide range of organic compounds. The use of [(11) C]carbon monoxide in transition metal-mediated coupling reactions has been explored by several groups during the last 15 years, and an impressive number of the synthesis of [carbonyl-(11) C]compounds have been published to date. The application of radical-mediated [(11) C]carbonylation has also been explored in some extent. However, the main limitations to apply this potential precursor in (11) C-labeling chemistry are low concentration, poor solubility in commonly used organic solvents, and low reactivity. A couple of technical solutions such as high-pressure reactor system, microfluidic system, and different approaches to confine [(11) C]CO to the reaction media at ambient pressure have been developed over the years. Although considerable advances in [(11) C]carbon monoxide chemistry have been reported in recent years, its application in positron emission tomography tracer development is still an area of work in progress. This review summarizes all contributions to the area of radiolabeling using [(11) C]carbon monoxide published between 1995 and 2014 and discusses the scope and limitations of this method in clinical positron emission tomography tracer development.
[（11）C]一氧化碳是用于标记多种有机化合物中羰基位置的一种有吸引力的前体。在过去15年中，多个研究小组探索了[（11）C]一氧化碳在过渡金属介导的偶联反应中的应用，迄今为止已发表了大量关于[羰基-（11）C]化合物合成的报道。自由基介导的[（11）C]羰基化反应的应用也在一定程度上得到了探索。然而，将这种潜在前体应用于（11）C标记化学的主要限制是浓度低、在常用有机溶剂中的溶解度差以及反应活性低。多年来已经开发了一些技术解决方案，如高压反应器系统、微流控系统以及在常压下将[（11）C]CO限制在反应介质中的不同方法。尽管近年来[（11）C]一氧化碳化学已取得了相当大的进展，但其在正电子发射断层显像示踪剂开发中的应用仍然是一个正在进行研究的领域。本综述总结了1995年至2014年间发表的使用[（11）C]一氧化碳进行放射性标记领域的所有研究成果，并讨论了该方法在临床正电子发射断层显像示踪剂开发中的适用范围和局限性。
