Van der Wildt Berend, Shen Bin, Chin Frederick T
Molecular Imaging Program at Stanford (MIPS), Department of Radiology, Stanford University, School of Medicine, Stanford, California, USA.
J Labelled Comp Radiopharm. 2018 Dec;61(14):1110-1114. doi: 10.1002/jlcr.3686. Epub 2018 Oct 25.
[ C] CO is a highly versatile synthon that allows for labeling at carbonyl positions of many molecules by means of transition metal-mediated carbonylation reactions. The intrinsic complexity of carbonylation reactions often requires tedious screening of reaction conditions for obtaining satisfying yields. Herein, a [ C] CO dispending system for performing multiple reactions with a single batch of cyclotron-produced [ C]CO is described. This semiautomated setup allows for more rapid and efficient screening of reactions and reaction conditions compared with the traditional "one beam for one reaction" strategy.
[碳-11]一氧化碳是一种用途广泛的合成子，可通过过渡金属介导的羰基化反应在许多分子的羰基位置进行标记。羰基化反应固有的复杂性通常需要对反应条件进行繁琐的筛选以获得满意的产率。本文描述了一种[碳-11]一氧化碳分配系统，用于使用一批回旋加速器生产的[碳-11]一氧化碳进行多个反应。与传统的“一个反应一束”策略相比，这种半自动化装置能够更快速、高效地筛选反应和反应条件。
