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从毛梗稀莶中分离得到的3 - O - 甲基黄酮的体外抗炎活性

In vitro anti-inflammatory activity of 3-O-methyl-flavones isolated from Siegesbeckia glabrescens.

作者信息

Kim Jae Yeon, Lim Hyo Jin, Ryu Jae-Ha

机构信息

College of Pharmacy, Sookmyung Women's University, 52 Hyochangwon-Gil, Yongsan-Gu, Seoul 140-742, Republic of Korea.

出版信息

Bioorg Med Chem Lett. 2008 Feb 15;18(4):1511-4. doi: 10.1016/j.bmcl.2007.12.052. Epub 2007 Dec 25.

DOI:10.1016/j.bmcl.2007.12.052
PMID:18178435
Abstract

Four flavones, 3,4'-O-dimethylquercetin (1), 3,7-O-dimethylquercetin (2), 3-O-methylquercetin (3) and 3,7,4'-O-trimethylquercetin (4) were isolated as the inhibitors of nitric oxide production in activated microglia (IC(50) values: 11.1, 4.2, 3.8, and 25.1 microM, respectively). They suppressed the expression of protein and mRNA of inducible nitric oxide synthase. Furthermore, compounds 2 and 3 showed scavenging activity of peroxynitrite with SC(50) values of 1.75 and 0.77 microM, respectively.

摘要

四种黄酮，3,4'-O-二甲基槲皮素（1）、3,7-O-二甲基槲皮素（2）、3-O-甲基槲皮素（3）和3,7,4'-O-三甲基槲皮素（4）被分离出来作为活化小胶质细胞中一氧化氮产生的抑制剂（IC(50)值分别为：11.1、4.2、3.8和25.1 microM）。它们抑制诱导型一氧化氮合酶的蛋白质和mRNA表达。此外，化合物2和3表现出对过氧亚硝酸盐的清除活性，SC(50)值分别为1.75和0.77 microM。

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