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70岁以上患者全膝关节置换术后生存率更高:一项随访8至12年的前瞻性研究。

Better survival of total knee replacement in patients older than 70 years: a prospective study with 8 to 12 years follow-up.

作者信息

Fernandez-Fernandez Ricardo, Rodriguez-Merchan E Carlos

机构信息

Ricardo Fernandez-Fernandez MD, E. Carlos Rodriguez-Merchan MD, PhD, Department of Orthopaedic Surgery, La Paz University Hospital, Madrid, Spain.

出版信息

Arch Bone Jt Surg. 2015 Jan;3(1):22-8. Epub 2015 Jan 15.

Abstract

BACKGROUND

Modern knee designs have popularized its use in younger patients due to its better performance. There remains uncertainty whether higher demands of these patients can affect implant survivorship.

PURPOSE

To assess whether modern knee designs have provided similar results in patients younger than 70 years versus older patients.

METHODS

We included 203 consecutive patients (236 knees) who underwent knee replacement for osteoarthritis with a mean follow-up of 11.4 years (range: 8.8 to 12). The mean age was 70 years (range: 31 to 85). Knee replacements were stratified into two groups: 109 were younger than 70 years and 127 were older than 70 years (70 years of age is the mandatory retirement age).

RESULTS

There were no significant pre-operative differences between groups with regards to knee alignment, alpha or beta angles, knee score or function score. Fourteen implants were radiographically loose at last follow up visit. Groups were matched in terms of demographic data. We found that patients older than 70 years had significantly better mean survivorship at 12 years. (97% vs. 88%; P=0.010). Patients under 70 years presented with a higher rate of polyethylene wear which was further associated with radiolucent lines in the femur and tibia as well as the presence of osteolysis. There was also an association between migration and presence of osteolysis.

CONCLUSIONS

Patients over 70 years old undergoing cemented total knee replacement for osteoarthritis showed better implant survivorship versus patients under 70 years old.

摘要

背景

现代膝关节设计因其更好的性能而在年轻患者中得到更广泛应用。这些患者的更高需求是否会影响植入物的存活率仍不确定。

目的

评估现代膝关节设计在70岁以下患者与老年患者中是否产生相似的结果。

方法

我们纳入了203例连续接受膝关节置换术治疗骨关节炎的患者(236个膝关节),平均随访11.4年(范围:8.8至12年)。平均年龄为70岁(范围:31至85岁)。膝关节置换术分为两组:109例年龄小于70岁,127例年龄大于70岁(70岁为法定退休年龄)。

结果

两组在膝关节对线、α或β角、膝关节评分或功能评分方面术前无显著差异。在最后一次随访时,有14个植入物在影像学上显示松动。两组在人口统计学数据方面相匹配。我们发现70岁以上患者在12年时的平均存活率显著更高。(97%对88%;P = 0.010)。70岁以下患者的聚乙烯磨损率更高,这进一步与股骨和胫骨的透亮线以及骨溶解的存在相关。移位与骨溶解的存在之间也存在关联。

结论

接受骨水泥全膝关节置换术治疗骨关节炎的70岁以上患者与70岁以下患者相比,植入物存活率更高。

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