Sun Li-Rong, Qing Chen, Zhang Yan-Li, Jia Shu-Yu, Li Zhong-Rong, Pei Shen-Ji, Qiu Ming-Hua, Gross Michael L, Qiu Samuel X
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, The Chinese Academy of Sciences, Kunming, Yunnan, PR China.
Beilstein J Org Chem. 2007 Jan 31;3:3. doi: 10.1186/1860-5397-3-3.
Two new cycloartane-type triterpene glycosides, namely cimicifoetisides A (1) and B (2), along with seven known compounds cimigenol, 25-O-acetylcimigenol, cimigenol 3-O-beta-D-xylopyranoside, 12beta-hydroxycimigenol 3-O-beta-D-xylopyranoside, cimigenol 3-O-alpha-L-arabinopyranoside, 25-deoxyshengmanol 3-O-beta-D-xylopyranoside and cimilactone A, were isolated from the rhizomes of Cimicifuga foetida. Their structures were elucidated as cimigenol 3-O-(2'-O-acetyl)-alpha-L-arabinopyranoside (1) and 25-O-acetylcimigenol 3-O-(2'-O-acetyl)-alpha-L-arabinopyranoside (2). Both compounds 1 and 2 exhibited potent cytotoxicity against rat EAC (Ehrlich ascites carcinoma) and MDA-MB-A231 (human breast cancer) cells with IC50 values of 0.52 and 6.74 microM for 1, and 0.19 and 10.21 microM for 2, suggesting their potential for further investigation as anti-cancer agents.
从升麻的根茎中分离出两种新的环阿尔廷型三萜糖苷，即升麻皂苷A（1）和升麻皂苷B（2），以及七种已知化合物升麻醇、25 - O - 乙酰升麻醇、升麻醇3 - O - β - D - 木吡喃糖苷、12β - 羟基升麻醇3 - O - β - D - 木吡喃糖苷、升麻醇3 - O - α - L - 阿拉伯吡喃糖苷、25 - 脱氧升麻醇3 - O - β - D - 木吡喃糖苷和升麻内酯A。它们的结构被鉴定为升麻醇3 - O -（2'-O - 乙酰基）-α - L - 阿拉伯吡喃糖苷（1）和25 - O - 乙酰升麻醇3 - O -（2'-O - 乙酰基）-α - L - 阿拉伯吡喃糖苷（2）。化合物1和2对大鼠艾氏腹水癌（EAC）和人乳腺癌MDA - MB - A231细胞均表现出较强的细胞毒性，化合物1的IC50值分别为0.52和6.74微摩尔，化合物2的IC50值分别为0.19和10.21微摩尔，表明它们作为抗癌剂具有进一步研究的潜力。
