Gyurkó Márton Dávid, Steták Attila, Sőti Csaba, Csermely Péter
Semmelweis University, Department of Medical Chemistry, Molecular Biology and Pathobiochemistry, Budapest, Ulloi ut 26, 1085 Hungary.
Mini Rev Med Chem. 2015;15(8):696-704. doi: 10.2174/1389557515666150219144336.
The Ras/mitogen activated protein kinase (MAPK) pathway has key importance in development, cell differentiation and senescence, tumorigenesis, learning and memory. The clinical manifestations associated with this highly conserved pathway are called RASopathies. Phenotypic features are diverse and overlapping, but cognitive impairment is a common symptom. Here, we propose an approach based on molecular networks that link learning, memory and forgetting to the RASopathies and various neurodegenerative and neurodevelopmental diseases such as Alzheimer's disease, Parkinson's disease and autism spectrum disorders. We demonstrate the cross-talks of the molecular pathways in RASopathies and memory and the role of compartmentalization in these processes. The approved drugs are also overviewed, and C. elegans is proposed as a viable model system for experimental exploration and compound target prediction.n.
Ras/丝裂原活化蛋白激酶（MAPK）通路在发育、细胞分化与衰老、肿瘤发生、学习与记忆中具有关键重要性。与这一高度保守通路相关的临床表现被称为RAS病。其表型特征多样且相互重叠，但认知障碍是常见症状。在此，我们提出一种基于分子网络的方法，该方法将学习、记忆和遗忘与RAS病以及各种神经退行性和神经发育性疾病（如阿尔茨海默病、帕金森病和自闭症谱系障碍）联系起来。我们展示了RAS病与记忆中分子通路的相互作用以及区室化在这些过程中的作用。还概述了已获批的药物，并提出秀丽隐杆线虫作为用于实验探索和化合物靶点预测的可行模型系统。
