通过乳果糖/呼气氢法和柳氮磺胺吡啶/磺胺吡啶法评估的口盲肠转运时间的比较。
Comparison of orocaecal transit times assessed by the lactulose/breath hydrogen and the sulphasalazine/sulphapyridine methods.
作者信息
Staniforth D H
机构信息
Clinical Pharmacology Unit, West Middlesex University Hospital, Isleworth.
出版信息
Gut. 1989 Jul;30(7):978-82. doi: 10.1136/gut.30.7.978.
Abstract
The lactulose/breath hydrogen and the sulphasalazine/sulphapyridine methods of assessing orocaecal transit time have been compared. In a two part crossover study in healthy normal subjects the median orocaecal transit time by the SLZ/SP method was 4.84 hours but only 2.92 hours by the lactulose/breath hydrogen method. Coadministration of lactulose and sulphazalazine to nine subjects with assessment of orocaecal transit time by hydrogen breath determination and plasma sulphapyridine assay gave orocaecal transit times of 2.33 and 2.25 hours respectively suggesting that the lactulose reduces transit time and that the lactulose/breath hydrogen method, which is so convenient to use, gives artificially low transit times. A third experiment was undertaken to compare the orocaecal transit times after 1.5 and 3.0 g sulphazalazine. The orocaecal transit times after the two doses were not statistically different.
摘要
对乳果糖/呼气氢法和柳氮磺胺吡啶/磺胺吡啶法评估口盲肠转运时间的方法进行了比较。在一项针对健康正常受试者的两部分交叉研究中，通过柳氮磺胺吡啶/磺胺吡啶法测得的口盲肠转运时间中位数为4.84小时，而通过乳果糖/呼气氢法测得的仅为2.92小时。对9名受试者同时给予乳果糖和柳氮磺胺吡啶，并通过呼气氢测定和血浆磺胺吡啶测定来评估口盲肠转运时间，结果分别为2.33小时和2.25小时，这表明乳果糖可缩短转运时间，且使用方便的乳果糖/呼气氢法得出的转运时间人为偏低。进行了第三个实验，比较服用1.5克和3.0克柳氮磺胺吡啶后的口盲肠转运时间。两剂药物后的口盲肠转运时间在统计学上无差异。
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